柴胡疏肝散联合奥美拉唑治疗老年消化性溃疡临床研究  

Clinical research of omeprazole combined quick Chaihu Shugansan powder for the treatment of elderly peptic ulcer

作　　者：刘伟[1] Liu Wei(Medical Gastroenterology,Puyang Oilfield General Hospital in Henan Province （Puyang 457000)

机构地区：[1]河南省濮阳市油田总医院消化内科,濮阳457000

出　　处：《陕西中医》2018年第6期749-751,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省卫生和计划生育委员会资助项目(201602158)

摘　　要：目的:探讨柴胡疏肝散联合奥美拉唑治疗对老年消化性溃疡(PUD)患者的疗效。方法:选取我院老年PUD患者94例,按照随机数表法将其分为对照组及联合用药组,对照组单纯应用奥美拉唑治疗,联合用药组在对照组的基础上联合柴胡疏肝散联合治疗,疗程均为6周。治疗结束后比较两组患者在临床症状评分、治疗效果以及不良反应发生情况。对患者进行为期1年的随访,观察比较两组患者复发率情况。结果:治疗前,对照组患者临床症状评分为(2.1±0.7)分,联合用药组患者为(2.2±0.6)分,两组患者临床症状评分比较无统计学意义(P>0.05)。治疗后,对照组患者临床症状评分为(1.3±0.5)分,联合用药组患者评分为(0.8±0.3)分,差异具有统计学意义(P<0.05)。复查电子胃镜结果表明,对照组患者治疗总有效率为85.0%,联合用药组患者总有效率为95.7%,差异具有统计学意义(P<0.05)。对照组患者不良反应发生率为27.7%,联合用药组患者为12.8%,差异具有统计学意义(P<0.05)。对照组中患者病情复发率为25.53%;观察组复发率为8.51%,两组比较差异具有统计学意义(P<0.05)。结论:奥美拉唑联合柴胡疏肝散治疗PUD效果显著,不良反应发生率及复发率低。Objective：To investigate the Chaihu Shugansan powder combined omeprazole for the curative effect of treatment of elderly patients with peptic ulcer.Methods：94 elderly patients with peptic ulcer in our hospital were selected,they were divided into control group and combined treatment group according to random number table method,the control group was treated with omeprazole alone,the combined treatment group combined with Chaihu Shugan powder combined treatment on the basis of the control group,the course of treatment was 6 weeks.After treatment,the clinical symptom scores,treatment effects and adverse reactions were compared between the two groups.Patients were followed up for 1 year,the recurrence rate of two groups of patients was observed and compared.Results：Before treatment,the score of clinical symptom in control group was（2.1±0.7）,the combined treatment group was（2.2±0.6）.There was no significant difference in clinical symptom scores between the two groups（P〉0.05）.After treatment,the score of clinical symptom in the control group was（1.3 ±0.5）,and the score of the combination group was（0.8±0.3）,the difference was statistically significant（P〈0.05）.Review of electronic endoscopy results showed that the total effective rate of the control group patients was 85.0%,the total effective rate of the combination group was 95.7%,the difference was statistically significant（P〈0.05）.The incidence of adverse reactions was 27.7%in the control group,and the combination group was 12.8%,the difference was statistically significant（P〈0.05）.The recurrence rate was 25.53%in the control group and 8.51%in the observation group,the difference between the two groups was statistically significant（P〉0.05）.Conclusion：The effect of omeprazole combined Chaihu Shugansan of treatment of peptic ulcer is significant,the incidence of adverse reactions and the recurrence rate is low,and it is worth to promote the clinical use.

关 键 词：消化性溃疡/中西医结合疗法 柴胡疏肝散/治疗应用 奥美拉唑 

分 类 号：R277.7[医药卫生—中医学]