退黄散外洗对新生儿黄疸胆红素及血清炎症因子水平的影响  

Effect of Tuihuangsan in the treatment of neonatal jaundice on bilirubin and serum inflammatory factors in children with jaundice

作　　者：王莉萍 张世昌 刘永兴 李怀营 Wang Liping;Zhang Shichang;Liu Yongxing;et al(Department of NICU,Xuchang Central Hospital in Henan Province（Xuchang 4G1000)

机构地区：[1]河南省许昌市中心医院NICU,许昌461000

出　　处：《陕西中医》2018年第6期784-786,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省科技攻关计划项目(2013048820)

摘　　要：目的:探讨退黄散外洗治疗新生儿黄疸对患儿胆红素及血清炎症因子水平影响。方法:选取本院116例新生儿黄疸患者作为研究对象,按入组先后顺序平均分成两组,每组58例,对照组常规西医治疗,研究组在对照组基础上加用退黄散(茵陈、大黄、栀子、丹参、泽泻、白术、甘草)外洗治疗,观察不同方法治疗后对新生儿胆红素和炎症因子影响性。结果:治疗3d后、治疗末和治疗前在CRP、AFP、DBIL、TBIL、IBIL含量上均显著下降(P<0.05)。研究组治疗3d后、治疗末在以上指标上改善水平均显著优于同时期对照组(P<0.05)。研究组血清胆红素水平恢复正常时间、黄疸持续时间、住院时间显著低于对照组,而每日血清胆红素降低值则显著高于对照组,两组比较差异有统计学意义(P<0.05)。研究组腹泻、皮疹、发热不良反应发生率为5.17%、5.17%、3.45%,显著低于对照组12.07%、12.07%、8.62%,两组比较差异有统计学意义(P<0.05)。对照组显效率36.21%、总有效率82.76%,研究组显效率50%、总有效率91.38%,研究组显著优于对照组(P<0.05)。结论:退黄散外洗治疗新生儿黄疸能降低胆红素和血清炎症因子,提高疗效,且不良较少。Objective：To investigate the effect of Tuihuangsan in the treatment of neonatal jaundice on the level of bilirubin and serum inflammatory factors in children.Methods：116 cases of neonatal jaundice patients in our hospital as the research object,according to the order were divided into 2 groups,58 cases in each group,the control group conventional western medicine treatment,research group in the control group based on the use of Tuihuang powder（Yin Chen,rhubarb,gardenia,ginseng,Atractylodes,Rhizoma alismatis,Dan licorice）washing treatment,observation of different treatment methods on bilirubin and inflammatory factors of newborn.Results：After 3 days treatment,end of treatment and before treatment in CRP,AFP,DBIL,TBIL,IBIL content decreased significantly（P〉0.05）.The study group after the treatment of 3 days,at the end of treatment in the above indicators of improvement were significantly better than in the control group（P〈0.05）.Study group serum bilirubin level the recovery time,the duration of jaundice,the hospitalization time was significantly lower than the control group,and serum bilirubin decreased daily value was significantly higher than the control group,there was significant difference between two groups（P〉0.05）.The study group diarrhea,rash,fever and %adverse reaction rate was 5.17%,5.17%,3.45%,12.07%,significantly lower than the control group 12.07%,8.62.There was significant difference between two groups（P〈0.05）.The curative effect,control group was 36.21%,the total efficiency of 82.76%,research group was 50%,the total efficiency of 91.38%,research group was significantly better than the control group（P〉0.05）.Conclusion：The treatment of jaundice in neonates can reduce bilirubin and serum inflammatory factors and improve the curative effect and the incidence of adverse reaction.

关 键 词：黄疸 新生儿 @退黄散 胆红素 炎症 

分 类 号：R722.17[医药卫生—儿科]