急性心肌梗死PCI术后应用红细胞生成素对临床疗效影响研究  

Effect of erythropoietin on clinical efficacy in patients with acute myocardial infarction after PCI

作　　者：陈文璐 张婧 徐晓辉 卢群[2] Chen Wenlu;Zhang Jing;Xu Xiaohui(Department of Cardiology,Xi＇an XD Group Hospital（Xi＇an 710077)

机构地区：[1]西电集团医院心血管内科,西安710077 [2]西安交通大学第一附属医院,西安710061

出　　处：《陕西医学杂志》2018年第6期736-738,共3页Shaanxi Medical Journal

基　　金：陕西省科技惠民计划项目(2016HM-04)

摘　　要：目的:探讨红细胞生成素(EPO)用于急性脑梗死PCI术后临床治疗效果。方法:将84例急性脑梗死行急诊PCI治疗的患者依照随机数字表法分为PCI组(42例)和PCI+EPO组(42例)。PCI组行PCI和常规药物治疗,PCI+EPO组在PCI组治疗方案上加用EPO治疗,比较两组术前及术后1周的心功能指标(LVESD、LVEDD、EV和AV),心肌损伤指标(Cys C、IMA)及炎症指标(CRP、IL-6、IL-10和MDC);随访6个月,比较两组心肌梗死面积、BNP含量及心血管不良事件的发生情况。结果:术前两组的各项指标间比较均无统计学差异(P>0.05);术后1周各指标有明显改变,且PCI+EPO组LVESD、LVEDD、IMA、CRP、IL-6、MDC明显低于PCI组(P<0.05),EV、AV、Cys C及IL-10明显高于PCI组(P<0.05);随访6个月,PCI+EPO组心肌梗死面积、血清BNP水平及心血管不良事件发生率均小于PCI组(P<0.05)。结论:急性心肌梗死应用PCI结合低剂量EPO多次给药治疗的安全性高,能明显的抑制机体炎症反应,减轻心肌损伤,改善心功能。Objective：To observe the effect of erythropoietin（EPO）on the treatment of acute cerebral infarction after PCI.Methods：84 cases of emergency treatment of acute cerebral infarction patients with PCI randomly divided into PCI group（42 cases）and PCI＋EPO group（42 cases）,group PCI underwent PCI and conventional drug treatment,PCI＋EPO treatment and EPO treatment in the PCI group,the two groups were compared before and after 1 weeks the heart function index（LVESD,LVEDD,EV and AV）,myocardial injury markers（Cys C,IMA）,inflammatory markers（CRP,IL-6,IL-10 and MDC）;after 6 months of follow-up,were compared between two groups of myocardial infarction area,the content of BNP and adverse cardiovascular events.Results：The preoperative indexes in two groups had no statistical difference among them（P〉0.05）;after 1 weeks,the index changes significantly,and the PCI＋EPO group of LVESD,LVEDD,CRP,IL-6,IMA,and MDC were lower than group PCI,AV,EV,Cys C and IL-10 were significantly higher than that of PCI group,compared with statistical difference（P〈0.05）;after 6 months of follow-up,PCI＋EPO group of myocardial infarction,the serum BNP level and incidence of adverse cardiovascular events were less than PCI group,there was significant difference（P〈 0.05）.Conclusion：PCI combined with low dose EPO is safe and effective in the treatment of acute myocardial infarction.It can obviously inhibit the inflammatory reaction,reduce myocardial injury and improve cardiac function.

关 键 词：心肌梗塞/治疗 红细胞生成素/治疗应用 @介入治疗 @心功能指标 @炎症反应指标 

分 类 号：R542.2[医药卫生—心血管疾病]