听性脑干反应偏侧优势用于孤独症谱系障碍患儿言语理解能力评估的回顾性对照研究  

Relationship between Laterality of Auditory Brainstem Response and Speech Comprehension in Children with Autism Spectrum Disorders:A Preliminary Retrospective Controlled Study

作　　者：戚敏[1] 黎志成[1] 张姝琪 曾祥丽[1] 岑锦添[1] 顾晶[1] QI Min;LI Zhi-cheng;ZHANG Shu-qi;ZENG Xiang-li;CEN Jin-tian;GU Jin(Department of Otolaryngology-Head and Neck, The Third Affiliated Hospital, Sun yat-sen University Guangzhou 510630, China)

机构地区：[1]中山大学附属第三医院耳鼻咽喉-头颈外科,广东广州510630

出　　处：《中山大学学报（医学版）》2018年第3期427-432,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省协同创新与平台环境建设专项(2015A020220005)

摘　　要：【目的】初步探讨孤独症谱系障碍患儿听性脑干反应的偏侧优势与言语理解能力之间的关系,为寻求孤独症谱系障碍患儿言语理解能力的客观评估指标奠定基础。【方法】回顾性分析2013年9月-2015年8月在本院儿童行为发育中心诊断为孤独症谱系障碍患儿的听性脑干反应结果,并与同期在本院耳鼻喉科治疗的分泌性中耳炎患儿痊愈后的听性脑干反应结果进行对比。根据纳入标准,最终纳入孤独症谱系障碍患儿84名,分泌性中耳炎痊愈患儿27名。【结果】孤独症谱系障碍组的Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期均显著长于对照组;同时,孤独症谱系障碍组的Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期存在显著的右侧优势,而对照组则未见这一现象;最后,高言语理解能力组的Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期存在显著的右侧优势,而低言语理解能力组未见这一现象。【结论】听性脑干反应的偏侧优势并非一个普遍存在的脑电现象。ASD患儿的偏侧优势可能与其言语理解能力的发展相关,ABR可能可作为ASD患儿言语理解能力的评估工具。【Objective】To explore the relationship between laterality of auditory brainstem response and speech com-prehension in children with autism spectrum disorders preliminarily.【Method】Review hearing diagnosis data in clinicalaudiology center from September 2013 to August 2015. We compare auditory brainstem responses in children with autismspectrum disorders（ASD group）and with other disorders（control group）,and we further divide children with autismspectrum disorders into two groups（high ability group and low ability group）in terms of their speech comprehension andcompare their auditory brainstem responses.【Result】The latencies of waves Ⅲ and V,and interpeak latencies I to Ⅲand I to V of the ASD were significantly prolonged than the control group. And the laterality of waves Ⅲ and V,and inter-peak latencies Ⅰ to Ⅲ and I to V present in the ASD group,but not in the control group. Meanwhile,the laterality ofwaves Ⅲ and V,and interpeak latencies Ⅰ to Ⅲ and I to V present in the high ability group,but not in the low abilitygroup.【Conclusion】Laterality was not a common phenomenon in auditory brainstem response,and it may be associatedwith the development of speech comprehension in children with autism spectrum disorders.

关 键 词：孤独症谱系障碍 听性脑干反应 偏侧优势 言语理解 

分 类 号：R76[医药卫生—耳鼻咽喉科]