A型肉毒素治疗雄激素源性脱发的临床观察  

Local Injections of Botulinum Toxin A in Treatment of Androgenetic Alopecia

作　　者：刘涛 李志武 丁街生 董秀芹 LIU Tao;LI Zhi-wu;DING Jie-sheng;DONG Xiu-qin(Department of Dermatology, Guangdong General Hospital//Guangdong Academy of Medical Sciences 510080, China)

机构地区：[1]广东省人民医院//广东省医学科学院皮肤科,广东广州510080

出　　处：《中山大学学报（医学版）》2018年第3期467-471,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2012A030400031)

摘　　要：【目的】了解A型肉毒素治疗雄激素源性脱发的疗效。【方法】72例雄激素源性脱发患者随机分为肉毒素治疗组(35例)和对照组(37例),治疗时间为半年,每组治疗前,治疗3个月和治疗6个月后拍照、评估。【结果】治疗3个月后,肉毒素治疗组毛发密度高于治疗前(P<0.05),但对照组没有区别治疗前后无差别(P>0.05),治疗6个月后肉毒素治疗组毛发密度高于治疗前(P<0.05),但与治疗3个月时无显著差异,对照组毛发密度高于治疗前,前后具有统计学差异(P<0.05);治疗6个月后,肉毒素治疗组的有效率为91.4%,对照组有效率为86.5%,两组间之间无显著差异(P>0.05)。两组均未发现明显副作用。【结论】A型肉毒素局部注射治疗雄激素源性脱发安全有效。【Objective】To determine the efficacy and safety of local injections of botulinum toxin A in the treatment of androgenetic alopecia.【Methods】72 male patients were randomly into botulinum toxin An group（n=35）and the control group（n=37）,the treatment time was 6 months. All the patients were photographed and evaluated,before the treatment,and 3 months and 6 months.【Results】After the treatment of half a year,a good result was observed,the hair density in the treatment group was higher after 3 months and 6 months than before the treatment（P〉0.05）,but there was no difference between the after 3 months and 6 months（P〈0.05）,the hair density in the control group was higher after 6 months than before the treatment and after 3 months（P〉0.05）,but there was no difference between the after 3 months and before the treatment（P〈0.05）;but there was no difference between the after 3 months and 6 months（P〉0.05）;After 6 months,the effective ratio and in two group were 91.4% and 86.5% in treated group,it showed no significant difference（P〉0.05）【Conclusion】the treatment of local injections of botulinum toxin A has a marked effect on androgenetic alopecia,it is safe and effective.

关 键 词：A型肉毒素 雄激素源性脱发 非那雄胺 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]