血清生长分化因子15、超敏C反应蛋白水平与老年冠心病患者冠状动脉病变严重程度的相关性研究  

Correlations of Serum Levels of GDF-15 and hs-CRP with Severity of Coronary Artery Lesion in Elderly Patients with Coronary Heart Disease

作　　者：李明 赵鸿彦[2] 张亚玲 赵小渝 程标 LI Ming;ZHAO Hong-yan;ZHANG Ya-ling;ZHAO Xiao-yu;CHENG Biao(Department of Cardiology,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People s Hospital（East Branch）,Chengdu 610101,China;Department of Cardiology,the Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China;Department of Nephrology,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital（East Branch）,Chengdu 610101,China;Department of Geriatric Cardiovascular Medicine,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital,Chengdu 610101,China)

机构地区：[1]四川省医学科学院.四川省人民医院(东院)心内科,四川省成都市610101 [2]遵义医学院附属医院心内科,贵州省遵义市563003 [3]四川省医学科学院.四川省人民医院(东院)肾内科,四川省成都市610101 [4]四川省医学科学院.四川省人民医院老年心血管内科,四川省成都市610101

出　　处：《实用心脑肺血管病杂志》2018年第4期24-28,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：贵州省科学技术基金项目(黔科合J字LKZ[2012]26号);四川省医学科学院.四川省人民医院苗圃科研课题(2014034)

摘　　要：目的探讨血清生长分化因子15(GDF-15)、超敏C反应蛋白(hs-CRP)水平与老年冠心病患者冠状动脉病变严重程度的相关性。方法选取2016年2—11月在四川省人民医院行冠状动脉造影的老年患者123例,根据冠状动脉造影结果分为冠心病组94例和非冠心病组29例;根据冠状动脉病变支数将冠心病组患者分为单支病变组28例、双支病变组35例、多支病变组31例,根据Gensini积分将冠心病组患者分为低分组24例(Gensini积分<32分)、中分组38例(Gensini积分32~82分)、高分组32例(Gensini积分>82分)。比较冠心病组与非冠心病组患者实验室检查指标,并比较不同冠状动脉病变支数、不同Gensini积分冠心病患者血清GDF-15、hs-CRP水平,血清GDF-15、hs-CRP水平与冠心病患者Gensini积分的相关性分析采用Pearson相关分析。结果冠心病组与非冠心病组患者血清总胆固醇(TC),三酰甘油(TG)、肌酐(Cr)、尿酸(UA)水平比较,差异无统计学意义(P>0.05);冠心病组患者血清HDL-C水平低于非冠心病组,血清低密度脂蛋白胆固醇(LDL-C)、超敏心肌肌钙蛋白I(hs-c Tn I)、GDF-15、hs-CRP水平高于非冠心病组(P<0.05)。多支病变组患者血清GDF-15、hs-CRP水平高于双支病变组、单支病变组,双支病变组患者血清GDF-15、hs-CRP水平高于单支病变组(P<0.05)。高分组患者血清GDF-15、hs-CRP水平高于中分组、低分组,中分组患者血清GDF-15、hs-CRP水平高于低分组(P<0.05)。Pearson相关分析结果显示,血清GDF-15(r=0.683)、hs-CRP(r=0.524)水平与老年冠心病患者Gensini积分呈正相关(P<0.01)。结论老年冠心病患者血清GDF-15、hs-CRP水平明显升高并与冠状动脉病变严重程度呈正相关,血清GDF-15、hs-CRP水平可在一定程度上反映老年冠心病患者冠状动脉病变严重程度。Objective To investigate the correlations of serum levels of GDF-15 and hs-CRP with severity of coronary artery lesion in elderly patients with coronary heart disease（CHD）. Methods A total of 123 elderly patients undergoing coronary angiography were selected in Sichuan Provincial People＇s Hospital from February to November 2016,and they were divided into CHD group（n=94）and non-CHD group（n=29）according to the coronary angiography results;patients in CHD group were divided into A1 group（with single-vessel lesion,n=28）,A2 group（with double-vessel lesions,n=35）and A3 group（with multiple-vessel lesions,n=31）according to the number of stenosed coronary arteries,into B1 group（with Gensini score less than 32,n=24）,B2 group（with Gensini score equal or over 32 but less than 82,n=38）and B3 group（with Gensini score over 82,n=32）according to Gensini score. Laboratory examination results were compared between CHD group and non-CHD group,serum levels of GDF-15 and hs-CRP were compared in A1 group,A2 group and A3 group,in B1 group,B2 group and B3 group,and Pearson correlation analysis was used to analyze the correlations of serum levels of GDF-15 and hs-CRP with Gensini score in elderly patients with CHD. Results No statistically significant differences of serum level of TC,TG,Cr or UA was found between CHD group and non-CHD group（P〉0.05）;serum HDL-C level in CHD group was statistically significantly lower than that in non-CHD group,while serum levels of LDL-C,hs-cTnI,GDF-15 and hs-CRP in CHD group were statistically significantly higher than those in non-CHD group（P〈0.05）. Serum levels of GDF-15 and hs-CRP in A3 group were statistically significantly higher than those in A1 group and A2 group,meanwhile serum levels of GDF-15 and hs-CRP in A2 group were statistically significantly higher than those in A1 group（P〈0.05）. Serum levels of GDF-15 and hs-CRP in B3 group were statistically significantly higher than those in B1 group and B2 group,meanwhile serum levels of GDF-15 an

关 键 词：冠心病 冠状动脉狭窄 老年人 生长分化因子15 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]