心型脂肪酸结合蛋白与Stanford B型主动脉夹层患者预后的关系研究  

Relationship between Heart-type Fatty Acid Binding Protein and Prognosis in Patients with Stanford B Type Aortic Dissection

作　　者：王海龙[1] 朱锋[1] 庞小华[1] 吴中杰[1] WANG Hai-long;ZHU Feng;PANG Xiao-hua;WU Zhong-jie(Chongqing Three Gorges Central Hospital,Chongqing 404000,Chin)

机构地区：[1]重庆三峡中心医院,重庆市404000

出　　处：《实用心脑肺血管病杂志》2018年第4期41-43,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨心型脂肪酸结合蛋白(H-FABP)与Stanford B型主动脉夹层患者预后的关系。方法选取2010年10月—2016年10月重庆三峡中心医院总院、重庆三峡中心医院急救分院、重庆三峡中心医院百安分院、重庆三峡中心医院平湖分院收治的Stanford B型主动脉夹层患者141例,根据预后分为预后良好组71例和预后不良组70例。比较两组患者一般资料和实验室检查指标,H-FABP与Stanford B型主动脉夹层患者预后的关系分析采用单因素、多因素Logistic回归分析。结果两组患者性别、年龄、治疗方案、总胆固醇、低密度脂蛋白胆固醇、三酰甘油及空腹血糖比较,差异无统计学意义(P>0.05);预后良好组患者中低血压、白细胞计数增高、H-FABP阳性者所占比例低于预后不良组(P<0.05)。单因素Logistic回归分析结果显示,H-FABP是Stanford B型主动脉夹层患者预后的影响因素[OR=1.67,95%CI(2.44,11.62),P=0.01];校正年龄、治疗方案、低血压及白细胞计数增高后,多因素Logistic回归分析结果显示,H-FABP是Stanford B型主动脉夹层患者预后的独立影响因素[OR=3.73,95%CI(1.02,13.67),P=0.04]。结论 H-FABP是Stanford B型主动脉夹层患者预后的独立影响因素,血清H-FABP水平≥7μg/L者预后较差,应引起临床重视。Objective To investigate the relationship between heart-type fatty acid binding protein（H-FABP）and prognosis in patients with Stanford B type aortic dissection. Methods From October 2010 to October 2016,a total of 141 patients with Stanford B type aortic dissection were selected in General Hospital,Emergency Branch,Baian Branch and Pinghu Branch of Chongqing Three Gorges Central Hospital,and they were divided into A group（with good prognosis,n=71）and B group（with poor prognosis,n=70）according to the prognosis. General information and laboratory examination results were compared between the two groups,univariate and multivariate Logistic regression analysis were used to analyze the relationship between H-FABP and prognosis in patients with Stanford B type aortic dissection. Results No statistically significant differences of gender,age,therapeutic regimen,TC,LDL-C,TG or FPG was found between the two groups（P〉0.05）;proportion of patients with hypotension,with WBC elevation,with positive H-FABP in A group was statistically significantly lower than that in B group,respectively（P〈0.05）. Univariate Logistic regression analysis results showed that,H-FABP was one of influencing factor of prognosis in patients with Stanford B type aortic dissection[OR=1.67,95%CI（2.44,11.62）,P=0.01];after correction of age,therapeutic regimen,hypotension and WBC elevation,multivariate Logistic regression analysis results showed that,H-FABP was an independent influencing factor of prognosis in patients with Stanford B type aortic dissection[OR=3.73,95%CI（1.02,13.67）,P=0.04]. Conclusion H-FABP is an independent influencing factor of prognosis in patients with Stanford B type aortic dissection,the prognosis in patients with serum H-FABP level equal or over 7 μg/L is relatively poor,which should pay attention to.

关 键 词：主动脉夹层 STANFORD B型 心型脂肪酸结合蛋白 预后 

分 类 号：R543.16[医药卫生—心血管疾病]