心-踝血管指数联合颈动脉内中膜厚度对冠状动脉粥样硬化的诊断价值  

Diagnostic Value of Cardio-Ankle Vascular Index Combined with Carotid Intima-Media Thickness in Coronary Atherosclerosis

作　　者：李博[1] 朱平先[2] 吴清华[3] 方胜先[1] 黄雪兰[1] 李家梅[1] LI Bo;ZHU Ping-xian;WU Qing-hua;FANG Sheng-xian;HUANG Xue-nan;LI Jia-mei(Department of Cardiology ,Longgang District Center Hospital of Shenzhen , Shenzhen 518116, China;Department of Cardiology, Longgang District People ＇ s Hospital of Shenzhen , Shenzhen 518172, China;Department of Cardiology, the Second Affiliated Hospital of Nanchang University , Nanchang 330006, China)

机构地区：[1]深圳市龙岗中心医院心内科,广东深圳518116 [2]深圳市龙岗区人民医院心内科,广东深圳518172 [3]南昌大学第二附属医院心内科,南昌330006

出　　处：《南昌大学学报（医学版）》2018年第2期53-56,68,共5页Journal of Nanchang University：Medical Sciences

基　　金：深圳市龙岗区科技发展资金(YLWS20150513165735387)

摘　　要：目的探讨心-踝血管指数(CAVI)联合颈动脉内膜厚度(IMT)对于冠状动脉粥样硬化的诊断价值。方法选取2015年2月至2017年2月间在龙岗中心医院心内科及协作医院疑诊冠心病行冠脉造影的患者176例为研究对象,依据Gensini评分情况分为A组(0分)、B组(1~80分)、C组(81~160分),测量并比较各组患者CAVI及IMT值,采用ROC曲线分析CAVI、IMT对于冠状动脉粥样硬化的诊断价值。结果 3组患者CAVI、IMT值比较差异有统计学意义(P<0.05);CAVI、IMT值与Gensini评分呈正相关性(r=0.542,P=0.000;r=0.254,P=0.001);单因素ROC曲线分析,CAVI值对冠状动脉粥样硬化诊断的敏感度较IMT升高(76.6%比58.6%);CAVI联合IMT值对冠状动脉粥样硬化诊断的敏感度可达91.7%,优于CAVI、IMT单独检测,但特异度有所下降。结论CAVI、IMT与冠状动脉粥样硬化严重程度有关,二者联合检测可显著提高对冠状动脉粥样硬化的诊断敏感度。Objective To investigate the diagnostic value of cardio-ankle vascular index（CAVI）combined with carotid intima-media thickness（IMT）in coronary atherosclerosis.Methods A total of 176 patients undergoing coronary angiography in the Department of Cardiology of Longgang Central Hospital and Cooperative Hospital from February 2015 to February 2017 were selected as the subjects.According to the Gensini scores,these patients were divided into group A（0）,group B（1-80）and group C（81-160）.The CAVI and IMT were compared among the three groups.The ROC curves were used to analyze the values of CAVI and IMT in the diagnosis of coronary atherosclerosis.Results There were significant differences in CAVI and IMT among the three groups（P〈0.05）.The CAVI and IMT were positively correlated with Gensini scores（r=0.542,P=0.000;r=0.254,P=0.001）.Univariate ROC curve analysis showed that the sensitivity of CAVI was higher than that of IMT for diagnosing coronary atherosclerosis（76.6% vs.58.6%）.Compared with CAVI or IMT alone,the combination of CAVI and IMT increased the sensitivity（91.7%）but decreased the specificity for diagnosing coronary atherosclerosis.Conclusion The CAVI and IMT are related to the severity of coronary atherosclerosis.The combined detection of CAVI and IMT can significantly improve the diagnostic sensitivity for coronary atherosclerosis.

关 键 词：心-踝血管指数 颈动脉内膜厚度 冠状动脉粥样硬化 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]