早产儿感染血清PCT、CRP、IL-6水平的变化及临床意义  

Changes and Clinical Significance of Serum PCT,CRP and IL-6 Levels in Premature Infants with Infection

作　　者：叶永灿 黄少彬[1] 吴童[1] YE Yong-can;HUANG Shao-bin;WU Tong(Department of Pediatrics, Bao＇an District Songgang People＇s Hospital of Shenzhen , Shenzhen 518105, China)

机构地区：[1]深圳市宝安区松岗人民医院儿科,广东深圳518105

出　　处：《实用临床医学（江西）》2018年第3期58-59,107,共3页Practical Clinical Medicine

基　　金：深圳市宝安区科技计划社会公益项目(2012177)

摘　　要：目的探讨早产儿感染血清降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平的变化及其临床意义。方法将60例早产儿根据临床诊断结果分为感染组和非感染组,每组30例。分别检测2组血清PCT、CRP、IL-6的水平,比较2组各检测指标的差异。结果感染组血清PCT、CRP、IL-6水平均明显高于非感染组(均P<0.05)。PCT诊断早产儿感染的敏感性为96.67%、特异性为83.33%,IL-6敏感性为83.33%、特异性为66.67%,CRP敏感性为76.67%、特异性为70.00%。PCT诊断早产儿感染的敏感性、特异性均明显高于IL-6和CRP(均P<0.05)。结论 IL-6、PCT、CRP检测对早产儿感染均有一定的诊断价值,而PCT敏感性、特异性均优于CRP和IL-6,可为临床合理用药提供指导。Objective To explore the changes in serum procalcitonin（PCT）,C-reactive protein（CRP）and interleukin-6（IL-6）levels and their clinical significance in premature infants with infection.Methods According to the clinical diagnosis results,60 premature infants were divided into infection group and non-infection group,with 30 infants in each group.Serum levels of PCT,CRP and IL-6 were detected in both groups.Results The levels of PCT,CRP and IL-6 in infection group were significantly higher than those in non-infection group（P〈0.05）.The sensitivity in diagnosing infection was 96.67%for PCT,83.33%for IL-6,and 76.67%for CRP.The specificity in diagnosing infection was 83.33%for PCT,66.67%for IL-6,and 70.00% for CRP.The sensitivity and specificity of PCT were significantly higher than those of IL-6 and CRP（P〈0.05）.Conclusion The IL-6,PCT and CRP detection is valuable for diagnosis of infection and provides guidance for clinical rational drug use in premature infants.However,the specificity and sensitivity of PCT are higher than those of CRP and IL-6.

关 键 词：感染 降钙素原 C-反应蛋白 白细胞介素-6 血清 早产儿 

分 类 号：R446.1[医药卫生—诊断学] R722[医药卫生—临床医学]