血清甘胆酸水平在ICP产妇新生儿预后评价中的应用价值  

Application value of serum cholylglycine level on the prognosis evaluation of neonates in maternals with intrahepatic cholestasis of pregnancy

作　　者：路海荣 宋荟琴 LU Hai-rong;SONG Hui-qin(Xianyang Rainbow Hospital,Xianyang 712000,China)

机构地区：[1]咸阳彩虹医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2018年第15期136-137,共2页Clinical Research and Practice

摘　　要：目的探讨血清甘胆酸(CG)水平在妊娠期肝内胆汁淤积症(ICP)产妇新生儿预后评价中的应用价值。方法选取我院95例ICP产妇作为研究组,并选取同期来我院分娩的95例正常产妇作为对照组,所有产妇均行血清CG检测,比较两组血清CG水平并分析CG对新生儿结局的影响。结果研究组产妇血清CG水平显著高于对照组(P<0.05)。研究组新生儿宫内窘迫、早产、羊水粪染、新生儿窒息及死亡的发生率均显著高于对照组,新生儿Apgar评分均显著低于对照组(P<0.05)。随着产妇CG水平的升高,新生儿宫内窘迫、早产、羊水粪染、新生儿窒息及新生儿死亡的发生率升高,新生儿Apgar评分降低(P<0.05)。结论 ICP产妇的血清CG水平将直接影响新生儿预后,且血清CG水平越高对新生儿预后的影响越大,因此临床应加强对ICP产妇CG水平的检测,并给予针对性的治疗。Objective To explore the application value of serum cholylglycine （CG） level on the prognosis evaluation of neonates in patients with intrahepatic cholestasis of pregnancy （ICP）. Methods A total of 95 maternals ICP in our hospital were selected as the study group, and 95 cases of normal maternals who delivered in our hospital during the same period were set as the control group. All maternals performed serum CG tests, and the serum CG levels were compared between the two groups, and the effects of CG on neonatal outcomes were analyzed. Results The serum CG level in the study group was significantly higher than that in the control group （P〈0.05）. The incidence of neonatal intrauterine distress, preterm birth, meconium-stained amniotic fluid, neonatal asphyxia and death in the study group were significantly higher than those in the control group, and the neonatal Apgar scores were significantly lower than those in the control group （P〈0.05）. With the increase of maternal CG level, the incidence of neonatal intrauterine distress, preterm birth, meconium-stained amniotic fluid, neonatal asphyxia and death increased, and the neonatal Apgar score decreased （P〈0.05）. Conclusion The serum CG level of ICP maternals will directly affect the neonatal prognosis, and the higher the level of serum CG, the greater the impact on the neonatal prognosis, so CG levels in ICP maternals should be strengthened and targeted therapy should be given.

关 键 词：血清CG 妊娠期肝内胆汁淤积症(ICP) 新生儿预后 APGAR评分 

分 类 号：R714.7[医药卫生—妇产科学]