没食子儿茶素促进脂肪细胞吸收葡萄糖研究  

(-)-Gallocatechin promotes glucose uptake in adipocytes

作　　者：张伟云 王青 姚芳华 陈全成[2] ZHANG Weiyun;WANG Qing;YAO Fanghua;CHEN Quancheng(Xiamen Key Laboratory of Biotechnology of Chinese Traditional Medicine;Fujian Provincial Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Developmen;College of Pharmacy, Xiamen Medical College ,Xiamen 361023, China;2. School of Pharmaceutical Sciences ,Xiamen University ,Xiamen 361102, Chin)

机构地区：[1]福建省厦门市中药生物工程重点实验室福建省中药精加工与健康产品开发重点研究室厦门医学院药学系,福建厦门361023 [2]厦门大学药学院,福建厦门361102

出　　处：《上海中医药杂志》2018年第7期85-88,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81773601);福建省卫生系统中青年骨干人才培养项目2015年资助计划基础项目;厦门市卫计委资助项目(2015-ZQN-JC-45);福建省自然科学基金计划资助项目(2015J01065);福建省教育厅2015年第二批高等学校优秀学科(专业)带头人赴海外访学研修资助项目[闽教人(2015)103号];福建省厦门市科技局科技计划高校创新项目(3502Z20143026);福建省厦门市科技局科技计划项目(3502Z20144031);厦门医学院科研项目(Z2013-12;Z2013-25)

摘　　要：目的探讨没食子儿茶素对脂肪细胞在高浓度葡萄糖条件下吸收葡萄糖的作用。方法应用3T3-L1前脂肪细胞分化模型,测定在脂肪细胞中没食子儿茶素对葡萄糖吸收的作用和对3T3-L1前脂肪细胞分化的影响。结果没食子儿茶素可促进脂肪细胞中高浓度葡萄糖(30 mmol/L)条件下由胰岛素刺激的葡萄糖吸收,加快3T3-L1前脂肪细胞的分化。结论没食子儿茶素可增加脂肪细胞葡萄糖吸收并促进3T3-L1前脂肪细胞分化,提示没食子儿茶素可有效改变血糖浓度和改善胰岛素抵抗。Objective To explore the effects of（-）-Gallocatechin on the glucose uptake when the adipocytes were treated with high concentration of glucose.Methods The effects of（-）-Gallocatechin on glucose uptake and differentiation of 3 T3-L1 preadipocytes were detected using a 3 T3-L1 preadipocytes differentiation model.Results The（-）-Gallocatechin increased insulin-stimulated glucose uptake in adipocytes under the condition of high-concentration glucose（ 30 mmol/L） and accelerated the differentiation of 3 T3-L1 preadipocyte.Conclusion The（-）-Gallocatechin increases the glucose uptake in adipocytes and promotes the differentiation of 3 T3-L1 preadipocytes,which suggests that（-）-Gallocatechin may effectively improve the glycemic control and ameliorate the insulin resistance.

关 键 词：没食子儿茶素 葡萄糖吸收 3T3-L1前脂肪细胞分化 

分 类 号：R285[医药卫生—中药学]