Discovery and biosynthesis of thioviridamide-like compounds  

作　　者：Jian Tang Jingxia Lu Qunfeng Luo Huan Wang 

机构地区：[1]State Key Laboratory of Coordination Chemistry,Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University

出　　处：《Chinese Chemical Letters》2018年第7期1022-1028,共7页中国化学快报（英文版）

基　　金：supported by the 1000-Youth Talents Plan, NSF of China (No. 21778030);Natural Science Foundation of Jiangsu Province (No. BK20160640);the Fundamental Research Funds for the Central Universities

摘　　要：Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.

关 键 词：Natural products THIOAMIDES RiPPs BIOSYNTHESIS 

分 类 号：O629.72[理学—有机化学]