离子液体提取金银花中绿原酸的研究  

Extraction of chlorogenic acid from Jinyinhua(Lonicerae Japonicae Flos) by ionic liquid

作　　者：周惠燕[1] 陈珏[2] 徐蓓华[1] ZHOU Huiyan;CHEN Jue;XU Beihua(Department of Pharmaceutical Sciences, Zhejiang Pharmaceutical College, Ningbo 315100, China;Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China)

机构地区：[1]浙江医药高等专科学校制药工程学院,浙江宁波315100 [2]浙江大学宁波理工学院,浙江宁波315100

出　　处：《上海中医药杂志》2018年第5期83-86,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：浙江省教育厅高校科研项目(Y201330228);浙江省宁波市自然科学基金项目(2014A610212)

摘　　要：目的建立离子液体提取金银花中绿原酸的最佳方法。方法分别考察并优化了离子液体微波法和离子液体水浴加热法提取金银花中绿原酸的条件,并进行了比较。结果优选出最佳提取方法为:V_([C4MIN][BF4])/V_水为4∶11的离子液体水溶液、液料比为30、400 W微波提取2.5 min。在该工艺条件下绿原酸平均得率为为3.238%。结论该方法不仅提取率最高,而且快速、环保、节能。Objective To establish the optimum method of extracting chlorogenic acid from Jinyinhua（ Lonicerae Japonicae Flos） by ionic liquid. Methods The conditions of extraction of chlorogenic acid from Jinyinhua（ Lonicerae Japonicae Flos） by ionic liquid microwave and ionic liquid bath heating were investigated and optimized,respectively,and the comparison was made. Results The optimum extraction method was as followed： the composition proportion in aqueous solution of ionic liquid was V（[C4 MIN][BF4]）/V（water） as 4/11,the ratio of liquid to material was 30,the extraction process was performed by 400 W microwave for 2.5 minutes.The average yield of chlorogenic acid was 3.238% under this processing condition. Conclusion The method is fast,environmentally friendly and energy saving,with higher extraction rate.

关 键 词：绿原酸 离子液体 微波法 水浴加热法 

分 类 号：R284.2[医药卫生—中药学]