地西泮联合苯巴比妥治疗小儿热性惊厥的临床疗效及患儿血清学改变  

Clinical efficacy of diazepam combined with phenobarbital in the treatment of convulsion in children and its serological change

作　　者：戴上康[1] 吴元芳[1] 余洽超[1] 吴楚婷 DAI Shangkang;WU Yuanfang;YU Qiachao;WU Chuting(Department of Pediatrics,Kaiping Central Hospital,Kaiping 529300,Chin)

机构地区：[1]广东省开平市中心医院儿科,广东开平529300

出　　处：《中国医药科学》2018年第10期16-19,共4页China Medicine And Pharmacy

摘　　要：目的评价地西泮联合苯巴比妥治疗小儿热性惊厥的临床疗效及治疗前后患儿血清学改变。方法回顾性分析2015年4月~2016年10月于我院儿科治疗的热性惊厥患儿153例,根据其药物治疗方法不同分为观察组和对照组。其中观察组81名患儿采用地西泮联合苯巴比妥治疗,对照组72名患儿采用单纯地西泮治疗。观察两组患儿药物起效时间、惊厥控制时间、临床疗效、预后以及治疗前后血清学指标神经元特异性性烯醇化酶(NSE)、S-100β蛋白、脑源性神经营养因子(BDNF)以及血浆神经肽Y(NPY)的改变。结果观察组药物控制时间和惊厥停止时间显著低于对照组,总有效率显著高于对照组,不良反应发生率显著低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患儿血清学指标差异无统计学意义(P>0.05);治疗后,两组患儿NSE、S-100β、BNDF、NPY水平显著降低,与治疗前比较差异有统计学意义(P<0.05),治疗后观察组患儿血清学指标低于对照组,差异有统计学意义(P<0.05)。结论地西泮联合苯巴比妥治疗小儿惊厥临床疗效确切,能够增加治疗有效率,降低不良反应的发生,降低NSE、S-100β、BNDF、NPY水平,临床应用前景广阔。Objective To evaluate the clinical efficacy of diazepam combined with phenobarbital in the treatment of febrile convulsion in children and the serological changes of children before and after treatment. Methods One hundred and fifty-three children with febrile convulsion treated in pediatrics department of our hospital from April 2015 to October 2016 were retrospectively analyzed.They were divided into observation group and control group according to their drug treatment methods.81 children in the observation group were treated with diazepam combined with Phenobarbital,while 72 children in the control group were treated with diazepam alone.The drug onset time,convulsion control time,clinical efficacy,prognosis and changes of serum indexes such as neuron specific enolase（NSE）,S-100β protein,brain-derived neurotrophic factor（BDNF） and plasma neuropeptide y（NPY） before and after treatment were observed in the two groups. Results The drug control time and convulsion stopping time of the observation group were significantly lower than those of the control group,the total effective rate was significantly higher than that of the control group,and the incidence of adverse reactions was significantly lower than that of the control group,the difference was statistically significant（P〈0.05）.Before treatment,there was no significant difference in serological indexes between the two groups（P〈0.05）.After treatment,the levels of NSE,S-100β,BNDF and NPY in the two groups were significantly lower than those before treatment,and the difference was statistically significant（P〈0.05）.After treatment,the serological indexes of children in the observation group were lower than those in the control group,the difference was statistically significant（P〈0.05）. Conclusion Diazepam combined with phenobarbital has a definite clinical effect in the treatment of infantile convulsion.It can increase the effective rate of treatment,reduce the occurrence of adverse reactions,reduce the levels of NSE,S-100β,BN

关 键 词：热性惊厥 地西泮 苯巴比妥 血清学指标 

分 类 号：R720.597[医药卫生—急诊医学]