抗SSB抗体与原发性干燥综合征女性患者临床的相关性  

Clinical correlation between anti-SSB antibody and female patients with primary Sjogren′s syndrome

作　　者：黄冬梅 唐琳[1] 邓明婷 HUANG Dong-mei;TANG Lin;DENG Mingting(Department of Rheumatology and Immunology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China)

机构地区：[1]重庆医科大学附属第二医院风湿免疫科,重庆400010

出　　处：《现代医药卫生》2018年第11期1611-1614,1618,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金资助项目(81771738)

摘　　要：目的探讨抗干燥综合征B(SSB)抗体与原发性干燥综合征女性患者临床的相关性。方法对2016年1月至2017年9月该科收治的63例原发性干燥综合征女性患者的临床表现及实验室数据进行回顾性分析。按抗RO52抗体、抗干燥综合征A(SSA)抗体、抗SSB抗体检查结果分为抗SSB抗体阳性组(A组)与抗SSB抗体阴性组(B组),以及抗RO52抗体阳性、抗SSA抗体阳性、抗SSB抗体阳性组(C组)与抗RO52抗体阳性、抗SSA抗体阳性、抗SSB抗体阴性组(D组)。结果抗SSB抗体阳性与出现复发性腮腺肿大、高球蛋白血症、类风湿因子(RF)阳性、贫血及抗RO52抗体阳性、抗着丝点抗体(ACA)阴性有关。A组患者中位RF、免疫球蛋白G(Ig G)、红细胞沉降率(ESR)水平均明显高于B组,C组患者出现高球蛋白血症、RF阳性及ACA阴性的概率均明显高于D组,中位RF、Ig G、ESR水平也均明显高于D组,差异均有统计学意义(P<0.05)。抗SSB抗体滴度与RF、Ig G、ESR水平呈正相关(P<0.05)。结论对不明原因出现复发性腮腺肿大、高球蛋白血症、RF阳性时,应早期进行抗SSB抗体检测,对出现抗SSB抗体阳性的干燥综合征患者应注意随访,警惕淋巴瘤的发生。Objective To explore the clinical correlation between anti-SSB antibody and female patients with primary Sogren′s syndrome. Methods The clinical manifestations and laboratory data in 63 female patients with primary Sjogren′s syn-drome in this hospital from January 2016 to September 2017 were retrospectively analyzed. According to the detection results of anti-RO52 antibody,anti-SSA antibody and anti-SSB antibody,the cases were divided into the anti-SSB antibody positive group（group A）,anti-SSB antibody negative group（group B）,anti-RO52 antibody positive,anti-SSA antibody positive and anti-SSB antibody positive group（group C）and anti-RO52 antibody positive,anti-SSA antibody positive and anti-SSB antibody negative group（group D）. Results The anti-SSB antibody positive were associated with the appearance of recurrent parotid enlargement,hyperglobulinemia,RF positive,anemia and anti-RO52 antibody positive,anti-ACA antibody negative. Median RF,Ig G and ESR levels in the group A were significantly higher than those in the group B,the probabilities of appearing hyperglobulinemia,RF positiveand anti-ACA antibody negative in the group C were significantly higher than those in the group D,and the median RF,Ig G and ESR levels were also significantly higher than those in the group D,the differences were statistically significant（P〈0.05）. The ti-ter of anti-SSB antibody was positively correlated with the RF,Ig G and ESR levels（P〈0.05）. Conclusion For unexplained appearance of recurrent parotid enlargement,hyperglobulinemia and RF positive,early anti-SSB antibody detection should be performed,the primary Sjogren′ s syndrome patients with anti-SSB antibody positive should be followed up and be vigilant for lymphoma occurrence.

关 键 词：干燥综合征 抗体 高丙种球蛋白血症 类风湿因子 血沉 

分 类 号：R593.2[医药卫生—内科学]