前列地尔联合依帕司他和甲钴胺治疗2型糖尿病周围神经病变的临床研究  

Clinical study of alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy

作　　者：王晓敏[1] 沈利兰[1] 何柏林 张立莹[1] 苟爱芳 Wang Xiaomin;Shen Lilan;He Bailin;Zhang Liying;Gou Aifang.(Department of Endocrinology, the First People＇s Hospital of Baiyin ,Baiyin, Gansu 730900, Chin)

机构地区：[1]白银市第一人民医院内分泌科,甘肃省白银730900

出　　处：《中国基层医药》2018年第13期1700-1703,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨前列地尔联合依帕司他和甲钴胺治疗2型糖尿病周围神经病变的疗效。方法选择白银市第一人民医院2014年1月至2016年6月收治的2型糖尿病周围神经病变患者120例，采用随机数字表法分为两组。观察组64例采用前列地尔、依帕司他和甲钻胺联合治疗，对照组56例采用前列地尔、甲钴胺联合治疗，两组疗程均为4周。比较两组治疗前后血糖、临床症状、不良反应、神经传导速度等指标。结果治疗后两组空腹血糖、餐后2h血糖均明显下降（t=18．20、17．61、15．75、23．69，均P〈0．05）；观察组腓肠神经传导速度、正中神经传导速度、尺神经传导速度均明显高于对照组（t=1．989、2．638、3．026、2．187、2．619、1．997，均P〈0．05）；观察组治疗总有效率明显高于对照组（95．3％比82．1％，χ^2=4．54，P〈0．05）；两组血糖及不良反应发生率差异均无统计学意义（t=0．267、0．176、0．695、0．658；χ^2=1．356，均P〉0．05）。结论前列地尔、依帕司他、甲钴胺联合治疗2型糖尿病周围神经病变的疗效良好。Objective To study the effect of alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy. Methods From January 2014 to June 2016,120 patients with type 2 diabetic peripheral neuropathy in the First People＇s Hospital of Baiyin were randomly divided into two groups according to the random number table method. 64 patients of the observation group were given the treatment of alprostadil, epalrestat combined with methylcobalamin. 56 patients of the control group were given the treatment of alprostadil and methylcobalamin. And the two groups were treated for 4 weeks. The blood glucose, clinical symptoms, adverse reaction, nerve conduction velocity index were compared between the two groups before and after treatment. Results The fasting blood glucose and 2 - hour postprandial blood glucose of the two groups after treatment were significantly decreased （ t = 18.20,17.61,15.75,23.69, all P 〈 0.05 ）, and the conduction velocity of the common peroneal nerve, the median nerve and the ulnar nerve in the observation group were significantly higher than those in the control group （t = 1. 989,2. 638,3. 026,2. 187,2. 619,1. 997, all P 〈 0.05 ）. The total effective rate of the observation group was significantly higher than that of the control group （95.3% vs. 82.1%, χ^2 = 4.54, P 〈 0.05 ）. There were no statistically significant differences in the blood glucose and the incidence rate of adverse reactions between the two groups （t = O. 267,0. 176,0. 695,0. 658, χ^2 = 1. 356, all P 〉0.05 ）. Conclusion Alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy has good effect.

关 键 词：糖尿病神经病变 前列地尔 依帕司他 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]