生长激素联合不同促排卵方案对卵巢储备功能减退高龄女性IVF-ET结局的影响  

Effects of growth hormone co-treatment within different ovarian stimulation protocol in vitro fertilization for advanced patients with diminished ovarian reserve

作　　者：郭莹 蒋向荣 杨娜 董丽霞 GUO Ying;JIANG Xiang-rong;YANG Na;DONG Li-xia.(Maternity and Child Health Care Hospital of Qinhuangdao, Centre for Assisted Reproduction, 06600)

机构地区：[1]秦皇岛市妇幼保健院,河北秦皇岛066000

出　　处：《中国优生与遗传杂志》2018年第6期132-134,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨生长激素(GH)联合不同的促排卵方案对卵巢储备功能减退的高龄患者体外受精-胚胎移植(IVFET)结局的影响。方法本法研究纳入了年龄≥35岁行IVF-ET治疗且卵巢储备功能减退的不孕患者86人,根据不同的促排卵方案,分为三组:长方案、短方案和拮抗剂方案,且每组均添加生长激素治疗。比较组间的临床资料、实验室数据、卵巢反应性及妊娠结局。结果与其它三种相比,短方案获卵率较低(P<0.01);与短方案和拮抗剂方案相比较,长方案的2PN受精率较高(P<0.01),但缺陷是长方案Gn的使用天数及使用量较多;长方案的临床妊娠率要高于其它三种促排卵方案,但无统计学意义。结论生长激素联合长方案可改善卵巢储备功能减退高龄患者IVF-ET过程中的卵巢的反应性及妊娠结局。Objective：This study aims to define the best protocol to be used with growth hormone in advanced patients with diminished ovarian reserve,with comparison performed to delineate which protocol offers the best cycle outcomes. Methods：Eighty-six patients with diminished ovarian reserve who were equals to or more than 35 years old were included. The patients were allocated into there groups receiving growth hormone（GH）as an adjuvant therapy added to long or short agonist protocol and antagonist protocols. The clinical data,laboratory data,ovarian response and pregnancy outcome were compared between the three groups. Results：The short/GH gave significantly lower mean number of oocytes when compared with the long/GH and antagonist/GH. Considering the number of fertilized oocytes,the long/GH showed significantly higher levels than short/GH and antagonist/GH. The main drawback is that it required significantly higher HMG dose and longer duration of stimulation. But,when considering the clinical pregnancy rates,there was a difference in favor of the long/GH but not reaching a statistically significant value. Conclusion：Long/GH protocol could improve ovarian response and pregnancy outcome in advanced patients with diminished ovarian reserve.

关 键 词：生长激素(GH) 卵巢储备功能减退(DOR) 长方案 短方案 拮抗剂方案 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]