趋化因子SDF-1在脂肪间充质干细胞向血管内皮细胞分化过程中的作用  

The Effects of Chemokine SDF-1 on ADSCs Differentiation into VECs

作　　者：赖德芳 王青 刘东军[1] Lai Defang;Wang Qing;Liu Dongjun(State Key Laboratory of Reproductive Regulation ＆ Breeding of Grassland Livestock, College of Life Sciences of Inner Mongolia University, Hohhot 010070, China)

机构地区：[1]内蒙古大学生命科学学院省部共建草原家畜生殖调控与繁育国家重点实验室,呼和浩特010070

出　　处：《中国细胞生物学学报》2018年第5期827-835,共9页Chinese Journal of Cell Biology

摘　　要：近年来,研究发现,组织的局部缺血、肾功能不全、癌症、心脑血管等疾病的发生都与血管发生病变有着密切的联系。因此,使病变的血管减少并恢复正常的功能一度成为细胞学领域的热点。目前研究发现,来源于脂肪组织的脂肪间充质干细胞(adipose derived stem cells,ADSCs)能被有效地诱导成为血管内皮细胞(vessel endothelial cells,VECs),并且诱导过程中具有关键作用的趋化因子也不断地被发现,如血管内皮生长因子(vascular endothelial growth factor,VEGF)、成纤维细胞生长因子(fibroblast growth factor,b FGF)、类胰岛素一号增长因子(insulin-like growth factors-1,IGF-1)、基质细胞衍生因子-1(stromal cell-derived factor-1,SDF-1/CXCL12)等;诱导因子的含量、诱导时间都直接影响着结果;体外培养的ADSCs也可以分泌一定含量的趋化因子来进一步促进血管的形成。该文对近年来关于趋化因子SDF-1对血管生成影响的相关研究进行了综述,希望为模式动物的建立及人类疾病的研究提供理论依据。Recently years, many researches demonstrate that tissues ischemia, renal insufficiency, cancer, heart and cerebral vessels diseases etc. are tightly related with vascular lesion. Therefore, reduce the vascular lesion and recover their normal function have been accepted as the hot topic of cytology. Adipose derived stem cells（ADSCs） derived from adipose tissues could be efficiently induced to vessel endothelial cells（VECs） in vitro, and more significant factors（chemokine） have been found during this process, such as VEGF, b FGF, IGF-1, SDF-1（CXCL12） etc.. Angiopoiesis results are affected by chemokine content and induction period. Furthermore, chemokine secreted by ADSCs also can promote the rates of angiopoiesis in vitro. The effects of the chemokine SDF-1 on angiopoiesis are summarized in this article in resent years. This article provides a theoretical references for the relative animal models establishment and human diseases research.

关 键 词：脂肪间充质干细胞 血管内皮细胞 趋化因子SDF-1 诱导 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]