冠状动脉介入治疗的女性患者绝经状态调查  

Investigation of menstrual status in female patients underwent percutaneous coronary intervention

作　　者：马茜[1] 周玉杰[1] 张琳琳[1] 王志坚[1] 赵迎新[1] MA Qian;ZHANG Linlin;WANG Zhijian;ZHAO Yingxin;ZHOU Yujie(Department of Cadiovasculogy, Beijing Anzhen Hospital, Capital Medical University, Belting Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心内科12病房,100029

出　　处：《心肺血管病杂志》2018年第6期496-501,509,共7页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家自然科学基金青年基金(81400324);国家自然科学基金面上项目(81770431);北京市自然科学基金面上项目(7182048);北京市医院管理局青年人才培养"青苗"计划(QML20160602);北京市医院管理局"登峰"计划专项经费资助(DFL20150601);北京市医院管理局"使命"计划专项经费资助(SML20180601);北京市医院管理局临床医学发展专项经费资助(编号:ZY201303);国家重点研发计划"精准医学研究"重点专项(2017YFC0908800)

摘　　要：目的:探讨冠状动脉介入治疗(PCI)的女性人群中,绝经女性比例以及多年的比例变化趋势。方法:筛选我院2002年1月1日至2016年12月31日,诊断冠心病首次住院治疗并行PCI治疗的女性患者。收集全部入选患者住院时年龄、末次月经时间。计算不同年份下未绝经、围绝经、绝经年龄≤46岁以及绝经年龄>46岁女性患者比率。分析不同年份中不同月经状态女性患者构成比,绘制构成比图,观察早期绝经构成比趋势。分析不同年份中不同月经状态女性平均住院年龄,绘制不同年份不同月经状态女性平均住院年龄折线图,观察绝经年龄≤46岁的女性平均住院年龄变化趋势。结果:研究共纳入女性患者22 061例。自2002年以来,冠心病介入治疗女性患者中46岁前绝经女性构成比呈增长趋势(P<0.05)[2002年,171例女性介入治疗患者中46岁前绝经女性18例(10.5%);2016年,2 877例女性介入治疗患者中46岁前绝经女性698例(24.3%)]。46岁前绝经女性平均住院年龄在2005年前后略有增长趋势,2005年之前,46岁前绝经女性平均住院年龄约为61岁。2005年之后,46岁前绝经女性患者平均住院年龄约64岁,但整体无增加或降低的变化趋势。结论:在冠心病介入治疗女性人群中,46岁前绝经女性常见,发生率近25%,较15年前呈增长趋势。冠心病介入治疗女性人群平均住院年龄15年来稳定,无增长或减低趋势,年龄约为65岁。Objective： Our study is To investigate the prevalence of postmenopausal women in women who underwent percutaneous coronary intervention and trends in the proportions of different years. Methods： In this retrospective,single-center study,female patients with CAD admitted in our hospital and underwent PCI from 2002. 1. 1 to 2016. 12. 31 were screened. Patients with accurate,especially menstruation records were enrolled. The prevalences of pre-menopause,peri-menopause,menopausal age ≤46 years old and menopause age 〉46 years old were investigated according to the patients＇ data including ages and the dates of last menstrual period. Patients＇ age and menopause prevalences trend charts were described by SPSS 19. 0 software. Results：A total of 13,894 patients were enrolled. The prevalence of early menopause has increased from 2002（ P〈0. 05）. 18（ 10. 5%） women from 171 female patients＇ menopause were before 46 years old in 2002. While in2016,the proportion reached to 24. 3% which means 698 women from 2877 female patients. Patients who menopause early were younger before 2005（ P〈0. 05）. But the ages increased to and stabilized at about 64 years old after that. Conclusion： In the interventional treatment of coronary heart disease in women,pre-46-year-old menopausal women are common,the incidence of nearly 25%,more than ten years ago showed an upward trend. The ages of CAD women underwent PCI are stable during these 10 years. The average is about 65 years old.

关 键 词：冠心病 女性 经皮冠状动脉介入治疗 绝经 

分 类 号：R54[医药卫生—心血管疾病]