Wnt信号通路对细胞增殖的调控  

Regulation of the Wnt signaling pathway on cell proliferation

作　　者：张宁芳[1] 高鹏飞[1] 成志敏[1] 乐宝玉 郭晓红[1] 李步高[1] 曹果清[1] LI Bu-Gao;CAO Guo-Qing(College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China)

机构地区：[1]山西农业大学动物科技学院,太谷030801

出　　处：《生命科学》2018年第5期551-558,共8页Chinese Bulletin of Life Sciences

基　　金：山西省科技创新重点团队(201605D131045-24);三晋学者支持计划(2016;2017);山西省"1331工程"

摘　　要：Wnt信号通路是一种在进化上高度保守的信号通路,在机体细胞的生长、发育以及代谢平衡等过程中发挥重要作用。细胞增殖是生物体生长、发育和遗传的基础。许多研究发现,Wnt信号通路中关键分子的变化会促进或抑制细胞增殖。现综述Wnt信号通路的组成、调控机理以及Wnt信号通路对细胞增殖的调控,并讨论基于Wnt信号通路影响细胞增殖的理论开发治疗癌症药物的可能性。Wnt signaling pathway is evolutionarily conserved, and has multiple biological functions during animal growth and development, and metabolic balance regulation. Cell proliferation is the base of genetics, growth and development. Previous studies demonstrate that alteration of Wnt signaling component either enhance or inhibit cell proliferation. In this review, the composition and regulation mechanisms of Wnt signaling pathway were summarized, and its effect on cell proliferation was reviewed. Additionally, possibility for developing new drugs targeted Wnt signaling pathway for cancer treatment was discussed.

关 键 词：WNT信号通路 细胞增殖 癌症 调控 

分 类 号：R392.5[医药卫生—免疫学] R730.2[医药卫生—基础医学]