脊髓损伤相关表观遗传学机制研究进展  

Research progress of spinal cord injury associated epigenetic mechanism

作　　者：张伯寅[1] 常鹏宇[2] 朱庆三[1] 尹若峰[1] Zhang Boyin;Chang Pengyu;Zhu Qingsan;Yin Ruofeng(Department of Orthopaedics, China - Japan Union Hospital of Jilin University, Changchun 130033 （ Zhang BY, Zhu QS, Yin RF;Department of Radiotherapy, the First Hospital of Jilin University, Changchun 130001, China （Chang PY)

机构地区：[1]吉林大学中日联谊医院骨科,长春130033 [2]吉林大学第一医院放疗科,长春130021

出　　处：《中华实验外科杂志》2018年第7期1387-1389,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81701225）;吉林省卫生与计划生育委员会青年科技骨干计划（2016Q037）;吉林大学白求恩培育计划（2015312）

摘　　要：脊髓损伤所导致的神经功能障碍尚无法治愈。近年来，随着全基因组测序及生物信息学技术的发展，大量与脊髓损伤及修复相关的表观遗传学调控靶点被陆续发现，这必将为脊髓损伤的基础及临床研究开辟崭新空间。鉴于此，本文将基于领域内最新进展及笔者近期研究工作对脊髓损伤相关表观遗传学调控机制进行综述。Neurological dysfunction caused by spinal cord injury is still incurable. Recently, with the development of whole genome sequencing and bioinformatics analysis, considerable spinal cord injury associated epigenetic regulatory targets have been discovered, which are promising for the spinal cord injury study. Accordingly, here we summarize the spinal cord injury associated epigenetic regulation mechanism of spinal cord injury based on the latest literature and studies of our group.

关 键 词：脊髓损伤 轴突再生 少突胶质细胞 表观遗传学 

分 类 号：R651.2[医药卫生—外科学]