益肾通督合剂治疗晚期强直性脊柱炎临床观察  

The Clinical Observation of Advanced Ankylosing Spondylitis Treated with Kidney-Nourishing and Du-Meridian-Dredging Mixture

作　　者：陈爱萍[1] 张秦[1] 邵培培[1] 马从[1] CHEN Ai-ping;ZHANG Qin;SHAO Pei-pei;MA Cong(Affiliated Beiing TCM Hospital of Beijing University of TCM, Beijing, China, 100010)

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《河南中医》2018年第6期899-902,共4页Henan Traditional Chinese Medicine

基　　金：北京市"薪火传承3+3"王为兰名家研究室(编号:2014-SZ-A-30)

摘　　要：目的:观察益肾通督合剂治疗晚期强直性脊柱炎(ankylosing spondylitis,AS)的临床疗效。方法:选取2016年1月至2016年12月本院收治的晚期强直性脊柱炎患者120例,随机分为治疗组和对照组,每组60例。治疗组脱落4例,对照组脱落10例。治疗组给予益肾通督合剂治疗,对照组给予柳氮磺吡啶治疗,两组疗程均为12周。观察两组治疗前后强直性脊柱炎脊柱痛VAS评分、夜间痛VAS评分、巴氏强直性脊柱炎活动指数(BASDAI)、巴氏强直性脊柱炎功能指数(BASFI)、修订的Schober试验、枕壁距、颈椎旋转度、扩胸度等变化情况,检测治疗前后血沉(erythrocyte sedimentation rate,ESR)和C反应蛋白(C reactive protein,CRP)水平。结果:治疗组治疗后BASDAI、脊柱痛VAS评分、夜间痛VAS评分、枕壁距、颈椎旋转度、扩胸度优于对照组(P<0.05),差异有统计学意义;两组治疗后ESR、CRP水平均优于治疗前(P<0.05),但组间比较无明显差异;治疗组有效率82.1%,对照组有效率70.0%,治疗组优于对照组(P<0.05),差异有统计学意义。结论:益肾通督合剂治疗晚期强直性脊柱炎疗效优于柳氮磺吡啶,且安全性较好。Objective：To observe the clinical curative effect of Kidney-Nourishing and Du-Meridian-Dredging Mixture on advanced ankylosing spondylitis（ AAS）. Methods：One hundred and twenty patients with AAS who were treated in our hospital from January2016 to December 2016 were chosen as the research subjects,and randomly divided into the treatment group and the control group,with 60 cases in each group. There were 4 cases in the treatment group and 10 cases in the control group who fell off. The ones in the treatment group were treated with Kidney-Nourishing and Du-Meridian-Dredging Mixture,while the ones in the control group were treated with sulfasalazine. The two groups were both treated for 12 weeks. Then changes of spinal pain VAS scores,nocturnal pain VAS scores,pasteurized ankylosing spondylitis index（ BASDAI）,barson ankylosing spondylitis function index（BASFI）,revised Schober test,occipital distance,cervical spine rotation,and chest enlargement before and after the treatment were observed in the two groups;erythrocyte sedimentation rate（ ESR） and C reactive protein（ CRP） levels before and after the treatment were detected. Results：After the treatment,BASDAI,spinal pain VAS scores,nocturnal pain VAS scores,occipital wall distances,cervical spine rotations,and chest expansion of the treatment group ere superior to those of the control group（ P〈0. 05）,and all the differences were statistically significant. The levels of ESR and CRP in the two groups were better than those before the treatment（ P〈0. 05）,but there was no significant difference between the groups. The effective rate of the treatment group was 82. 1% and that of the control group was 70%. The treatment group was better than the control group（ P〈0. 05）,the difference was statistically significant. Conclusion： Kidney-Nourishing and Du-Meridian-Dredging Mixture is better than sulfasalazine in the treatment of advanced ankylosing spondylitis,and its safety is better.

关 键 词：晚期强直性脊柱炎 益肾通督合剂 柳氮磺吡啶 血沉 C反应蛋白 

分 类 号：R274.981.55[医药卫生—中西医结合]