排石利胆汤治疗慢性胆囊炎临床研究  

The Clinical Research into Chronic Cholecystitis Treated with Li Dan Pai Shi Decoction

作　　者：孔悟华 郑太昌 KONG Wu-hua;ZHENG Tai-chang(Xuchang City TCM Hospital, Xuchang, Henan, China ,461000)

机构地区：[1]许昌市中医院,河南许昌461000

出　　处：《河南中医》2018年第6期920-922,共3页Henan Traditional Chinese Medicine

摘　　要：目的:研究排石利胆汤治疗肝胆气滞型慢性胆囊炎临床疗效。方法:选取2015年1月至2017年8月许昌市中医院肝胆外科门诊及住院治疗的患者慢性胆囊炎72例,均诊断为慢性胆囊炎肝胆气滞型,按照随机数字表法分为治疗组和对照组,每组36例。对照组参考《中国慢性胆囊炎、胆囊结石内科诊疗意见共识》给予常规治疗,治疗组在对照组治疗的基础上加用排石利胆汤治疗。比较两组治疗前后中医症状评分、胆囊收缩功能及胆囊壁厚度,检测两组血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和瘦素(leptin,LEP)水平。结果:治疗组治疗后上腹饱胀、右上腹痛、右上腹压痛和粪便评分均优于对照组,差异有统计学意义(P<0.01);治疗组有效率为91.67%,对照组有效率为75.00%,治疗组优于对照组(P<0.05),差异有统计学意义;治疗组治疗后胆囊收缩功能、胆囊壁厚度优于对照组(P<0.01),差异有统计学意义;治疗组治疗后血清TNF-α和LEP水平均优于对照组,差异有统计学意义(P<0.01)。结论:排石利胆汤治疗肝胆气滞型慢性胆囊炎,可显著改善患者症状,减少胆囊壁厚度,增加胆囊收缩功能,有助于下调患者血清TNF-α和LEP水平。Objective：To observe the clinical curative effect of Li Dan Pai Shi Decoction（ LDPSD） on chronic cholecystitis of liver and gallbladder qi stagnation type. Methods：From January 2015 to August 2017,seventy-two patients with chronic cholecystitis treated in outpatient Department of hepatobiliary surgery of Xuchang City TCM Hospital ho were diagnosed as chronic cholecystitis with liver and gallbladder stagnation were divided into the treatment group and the control group according to the random digital table method,with 36 cases in each group. The control group referred to The Common Treatment of Chinese Chronic Cholecystitis and Ccholecystolithiasis Medical Treatment Opinion,and the treatment group was treated with LDPSD on the basis of the control group. The scores of TCM symptoms,gallbladder contractile function and the thickness of gallbladder wall were compared between the two groups before and after the treatment,and the levels of serum tumor necrosis factor-α（ TNF-α） and leptin（ LEP） were measured. Results：After the treatment,the upper abdominal distention,right upper abdominal pain,right upper abdominal pain and stool score were superior to those of the control group,and all the differences were statistically significant（ P〈0. 01）. The effective rate of the treatment group was 91. 67%,and that of the control group was 75%,the treatment group was superior to the control group（ P〈0. 05）,the difference has statistical significance. After the treatment,the treatment group＇s gallbladder contraction function and gallbladder wall thickness were all better than those of the control group（ P〈0. 01）,and all the differences were statistically significant. The levels of serum TNF-α and LEP in the treatment group were all better than those of the control group,and all the differences were statistically significant（ P〈0. 01）. Conclusion： LDPSD has a remarkable clinical curative effect on chronic cholecystitis of liver and gallbladder qi stagnation type,can significantly imp

关 键 词：慢性胆囊炎 利胆排石汤 肝胆气滞型 肿瘤坏死因子-α 瘦素 胆囊收缩功能 胆囊壁厚度 

分 类 号：R259[医药卫生—中西医结合]