仙胶合剂对肝肾阴虚型卵巢早衰患者骨代谢的影响  

The Influence of Xianjiao Mixture on Bone Metabolism of Patients with Premature Ovarian Failure with Liver Kidney Yin Deficiency Syndrome

作　　者：卢军 陈燕芬 方米泥 杨翠玉 LU Jun;CHEN Yan-fen;FANG Mi-ni;YANG Cui-yu(Puning City TCM Hospital, Puning, Guangdong, China, 515300)

机构地区：[1]普宁市中医医院,广东普宁515300

出　　处：《河南中医》2018年第6期941-944,共4页Henan Traditional Chinese Medicine

摘　　要：目的:观察仙胶合剂对肝肾阴虚型卵巢早衰患者骨代谢的影响。方法:将48例肝肾阴虚型卵巢早衰患者随机分为观察组和对照组,每组各24例。对照组采用克龄蒙治疗,观察组采用仙胶合剂联合克龄蒙治疗。比较两组患者治疗前后促卵泡生成素(follicle-stimulating hormone,FSH)、雌二醇(estradiol,E2)、抗苗勒氏管激素(anti mullerian tube hormone,AMH)、腰椎骨密度、股骨颈骨密度、25-羟基维生素D3(25-hydroxyl vitamin D3,25-OH-VD3)、骨钙素(osteocalcin,OST)、降钙素(calcitonin,CT)及骨型碱性磷酸酶(bone alkaline phosphates,BAP)水平。结果:两组患者治疗后FSH水平明显降低,E2水平、AMH水平明显升高,差异有统计学意义(P<0.05);治疗后观察组患者FSH、E2、AMH水平改善明显优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后腰椎骨密度、股骨头骨密度明显增加,且观察组高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后25-OH-VD3水平升高,OST水平明显降低,差异有统计学意义(P<0.05);CT水平升高,BAP水平降低,但差异无统计学意义(P>0.05)。观察组患者治疗后25-OH-VD3、OST、CT、BAP水平改善明显优于对照组,差异有统计学意义(P<0.05)。结论:仙胶合剂可以改善卵巢早衰患者骨代谢,减少卵巢早衰患者骨质疏松的发生。To observe the influence of Xianjiao Mixture（ XJM） on bone metabolism of patients with premature ovarian failure（POF）with liver kidney yin deficiency syndrome. Methods：Forty-eight patients with POF with liver kidney yin deficiency syndrome were randomly divided into the observation group and the control group,with 24 cases in each group. The ones in the control group were treated with Climen,while the ones in the observation group were treated with Climen combined with XJM. Then the levels of follicle-stimulating hormone（ FSH）,estradiol（ E2）,anti mullerian tube hormone,（ AMH）,lumbar bone density,femoral neck bone density,25-hydroxyl vitamin D3（25-OH-VD3）,osteocalcin（ OST）,calcitonin（ CT） and bone alkaline phosphates（ BAP） before and after the treatment in the two groups were compared. Results：After the treatment,the level of FSH decreased significantly in the two groups,and the levels of E2 and AMH increased significantly（ P〈0. 05）,and the difference between them had statistical significance（ P〈0. 05）. The levels of FSH,E2 and AMH in the observation group were significantly better than those of the control group after the treatment（ P〈0. 05） and all the differences between them had statistical significance（ P〈0. 05）. Bone mineral density and femoral head bone mineral density increased significantly in the two groups after the treatment,and the observation group was higher than the control group（ P〈0. 05）,and all the differences between them had statistical significance（ P〈0. 05）. After the treatment,the level of 25-OH-VD3 in the two groups increased and the level of OST decreased significantly（ P〈0. 05）,and the differences were statistically significant（ P〈0. 05）. The level of CT increased and the level of BAP decreased,but the differences were not statistically significant（ P〈0. 05）. The levels of 25-OH-VD3,OST,CT and BAP in the observation group were significantly better than those in the control group after treatment�

关 键 词：卵巢早衰 仙胶合剂 克龄蒙 肝肾阴虚证 骨代谢 中医药疗法 中西医结合 

分 类 号：R271.911.75[医药卫生—中西医结合]