川芎嗪注射液联合羟苯磺酸钙对糖尿病视网膜病变患者血流变学及脂联素水平的影响  

Effect of Ligustrazine Injection Combined with Calcium Dobesilate on Hemorrheology and Adiponectin Levels in Patients with Diabetic Retinopathy

作　　者：任红苗[1] 高志娟 REN Hongmiao;GAO Zhijuan(Linyi Municipal Hospital of Traditional Chinese Medicine, Linyi 276002, Shandong, Chin)

机构地区：[1]临沂市中医医院

出　　处：《辽宁中医药大学学报》2018年第6期149-152,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省自然科学基金专项项目(ZR2009CL038)

摘　　要：目的：探讨川芎嗪注射液联合羟苯磺酸钙对糖尿病视网膜病变（DR）患者血流变学及脂联素水平的影响。方法：选择2015年4月—2017年4月我院接诊的92例DR患者为本研究对象,以随机数表法分为观察组（n=46）和对照组（n=46）,在糖尿病常规治疗基础上,对照组使用羟苯磺酸钙治疗,观察组联合川芎嗪注射液治疗,均连续治疗2个疗程。比较两组治疗前后全血低切黏度、全血高切黏度、血浆黏度、血小板聚集率、血清脂联素及视力、视野平均缺损程度的变化,并比较临床疗效。结果：治疗后,两组全血低切黏度、全血高切黏度、血浆黏度、血小板聚集率较治疗前均显著降低（P〈0.05）,观察组全血低切黏度、全血高切黏度、血浆黏度、血小板聚集率均明显比对照组低[（8.94±1.03）m Pa·s vs（10.12±1.12）m Pa·s,（4.54±0.47）m Pa·s vs（5.62±0.52）m Pa·s,（1.23±0.20）m Pa·s vs（1.65±0.23）m Pa·s,（52.73±6.50）%vs（60.17±7.82）%]（P〈0.05）;治疗后,两组血清脂联素较治疗前均显著升高（P〈0.05）,观察组血清脂联素明显比对照组高[（5.28±0.81）μg/m L vs（4.67±0.72）μg/m L]（P〈0.05）;治疗后,两组视力较治疗前均显著升高,视野平均缺损程度明显降低（P〈0.05）,观察组视力明显高于对照组,视野平均缺损程度明显低于对照组（P〈0.05）;观察组临床疗效总有效率明显高于对照组[89.13%（41/46）vs69.57%（32/46）]（P〈0.05）。结论：在DR患者中使用川芎嗪注射液联合羟苯磺酸钙效果显著,可有效改善血液流变学,升高脂联素的表达,缓解临床症状,临床应用价值高。Objective：To study effect of ligustrazine injection combined with calcium dobesilate on hemorrheology and adiponectin levels in patients with diabetic retinopathy（DR）. Methods：92 patients of DR who received therapy from April 2015 to April 2017 in our hospital were selected as research objects. According to random number table,those patients were divided into the observation group（n=46）and the control group（n=46）,on the basis of conventional treatment for diabetes mellitus,the control group was treated with calcium dobesilate,while the observation group was combined with ligustrazine injection,they were treated continuously for 2 courses. The changes of whole blood low shear viscosity,whole blood viscosity,plasma viscosity,platelet aggregation rate,serum adiponectin and vision,average extent of visual defect before and after treatment were compared between the two groups,and the clinical efficacy was compared. Results：After treatment,whole blood viscosity,whole blood viscosity,plasma viscosity and platelet aggregation rate of two groups were significantly lower than before treatment（P〈0.05）,the whole blood low shear viscosity,whole blood viscosity,plasma viscosity and platelet aggregation rate in the observation group were significantly lower than that of the control group[（8.94±1.03）m Pa·s vs（10.12±1.12）m Pa·s,（4.54±0.47）m Pa·s vs（5.62±0.52）m Pa·s,（1.23±0.20）m Pa·s vs（1.65±0.23）m Pa·s,（52.73%±6.50%）vs（60.17%±7.82%）]（P〈0.05）;after treatment,the serum adiponectin of the two groups were significantly higher than those before treatment（P〈0.05）,and the serum adiponectin in the observation group was significantly higher than that of the control group[（5.28±0.81）μg/m L vs（4.67±0.72）μg/m L]（P〈0.05）;after treatment,the vision of two group were significantly higher than before treatment,the average extent of visual defect was significantly reduced（P〈0.05）,and the vision in the observation group was significantly highe

关 键 词：糖尿病视网膜病变 川芎嗪注射液 羟苯磺酸钙 血液流变学 脂联素 

分 类 号：R587.2[医药卫生—内分泌]