天津市<8月龄婴儿麻疹、风疹、流行性腮腺炎抗体母婴配对研究  

Paired infant-maternal measles,mumps,and rubella antibody levels among infants less than 8 months old in Tianjin

作　　者：丁亚兴[1] 刘杨[1] 郝宝云 刘晓川 李国红 时同鑫 陈伟[1] 高志刚[1] 张颖[1] Ding Yaxing;Liu Yang;Hao Baoyun;Liu Xiaochuan;Li Guohong;Shi Tongxin;Chen Wei;Gao Zhigang;Zhang Ying(Tianfin Municipal Center for Disease Control and Prevention, Tianjin 300011, China;Binhai District Center for Disease Control and Prevention, Tianjin 300270, China;Xiqing District Center for Disease Control and Prevention, Tianfin 300380, China;Baodi District Center for Disease Control and Prevention, Tianjin 301800, China;Hexi Dis- trict Center for Disease Control and Prevention, Tianfin 300211, China)

机构地区：[1]天津市疾病预防控制中心,天津300011 [2]滨海新区疾病预防控制中心,天津300270 [3]西青区疾病预防控制中心,天津300380 [4]宝坻区疾病预防控制中心,天津301800 [5]河西区疾病预防控制中心,天津300211

出　　处：《中国疫苗和免疫》2018年第3期256-259,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的分析〈8月龄婴儿麻疹、风疹和流行性腮腺炎（流腮）母传抗体水平,探讨麻腮风联合减毒活疫苗（MMR）免疫策略。方法 2015-2016年在天津市抽取4个区采集〈8月龄婴儿及其母亲血清,采用酶联免疫吸附试验检测麻疹、风疹和流腮IgG抗体,分析婴儿母传抗体水平。结果共采集〈8月龄婴儿血清206份,麻疹、风疹、流腮抗体阳性率分别为50.00%、45.63%、62.62%（χ2=12.57,P=0.002）,抗体几何平均浓度分别为230.98m IU/ml、15.22IU/ml、179.02U/ml。206名配对母亲年龄中位数为27岁（19-42岁）,麻疹、风疹、流腮抗体阳性率分别为92.72%、87.86%和91.26%（χ2=3.01,P=0.222）。Logistic回归分析显示,7月龄婴儿与〈1月龄婴儿相比的麻疹、风疹、流腮易感性OR（95%CI）分别为15.16（4.46-51.45）、5.28（1.79-15.54）、1.82（0.64-5.14）。结论天津市育龄期女性麻疹和风疹抗体主要源于疫苗接种,婴儿母传抗体维持时间短;流腮抗体主要源于自然感染,婴儿母传抗体维持时间较长,8月龄接种MMR可能影响流腮免疫效果。Objective To examine the relationship between maternal and infant antibodies against measles, mumps, and rubella in infants 〈 8 months old in Tianjin and provide evidence pertinent to the measles-mumps-rubella combined vaccine （MMR） immunization strategy. Methods A cluster sampling strategy was used to select 4 districts of Tianjin to obtain serum samples of 〈 8-month-old infants and their mothers in 2015 and 2016. We used enzyme-linked immunosorbent assay （ELISA） to assess measles, rubella, and mumps antibody levels. Results Among 206 enrolled infants, sero-positivity rates for measles, rubella, and mumps were 50.00%, 45.63%, and 62.62% （χ2 = 12.57, P = 0.002）, respectively, and geometric mean concentrations were 230.98mIU/ml, 15.22IU/ml, and 179.02U/ml. Among the 206 matched mothers, median age 27 （19 -42） years, sero-positivity rates for measles, rubella, and mumps were 92. 72% , 87.86% , and 91.26% （χ2 =3.01, P =0. 222） , respec- tively. Logistic regression showed that the odds ratios （OR） （95% CI）for measles, rubella, and mumps susceptibility among 7-month-olds vs 〈 1-month-olds were 15.16 （ 4. 46 - 51.45 ） , 5.28 （ 1.79 - 15.54）, and 1.82 （0. 64 -5.14） , respectively. Conclusions Measles and rubella antibodies among childbearing-age women came mainly from vaccination; maternal antibodies for these 2 diseases lasted for only a short time in infants. Mumps antibodies among childbearing-age women came mainly from natural infection, and maternal antibodies lasted longer in the infants. Maternal antibodies at 8 months of age may influence the immune response to the mumps component of MMR vaccine when given at 8 months.

关 键 词：麻疹 风疹 流行性腮腺炎 母传抗体 

分 类 号：R181.1[医药卫生—流行病学] R511.1[医药卫生—公共卫生与预防医学]