双氯芬酸钠栓剂和曲马多针剂用于儿童骨折术后镇痛的对比研究  

Comparison of Postoperative Analgesia Effects between Diclofenac Sodium Suppository and Tramadol Injection in Children with Fracture

作　　者：郑敏之 薛彬[1] 林卡娜 Zheng Minzhi;Xue Bin;Lin Kana(Shanghai Children＇ s Medical Center Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心,上海200127

出　　处：《儿科药学杂志》2018年第7期13-15,共3页Journal of Pediatric Pharmacy

摘　　要：目的:比较双氯芬酸钠栓剂和曲马多针剂用于儿童骨折术后镇痛的效果。方法:将150例骨折手术的患儿随机分为A、B两组各75例,A组术后立即使用双氯芬酸钠栓剂塞肛,B组术后静脉注射曲马多,分别记录术后1 h、2 h、4 h、8 h、12 h、24 h东安大略儿童医院疼痛评分(CHEOPS)及术后不良反应发生情况。结果:A组和B组术后疼痛镇痛效果良好,在术后1 h、2 h、4 h、8 h、12 h、24 h CHEOPS比较差异无统计学意义(P>0.05)。A组不良反应发生率为10.67%(8/75),B组不良反应发生率为34.67%(26/75),两组比较差异有统计学意义(χ~2=12.323,P<0.01)。两组患儿均未发现药物过敏、呼吸抑制等严重不良反应。结论:双氯芬酸钠栓剂用于骨折术后镇痛的效果与曲马多针剂无差异,但不良反应更少,用法更简单。Objective： To compare the postoperative analgesia effects between diclofenac sodium suppository and tramadol injection in children with fracture. Methods： One hundred and fifty children undergoing fracture surgery were randomly divided into group A and group B. Group A was treated with diclofenac sodium suppository and group B received intravenous tramadol injection after fracture surgery. The CHEOPS pain scores and postoperative adverse drug reactions were recorded at 1 h,2 h,4 h,8 h,12 h and 24 h after surgery. Results： The postoperative analgesia effects were good in both groups after operation,and there was no statistically significant difference in CHEOPS pain scores at 1 h,2 h,4 h,8 h,12 h and 24 h after surgery（ P〉 0. 05）. The incidence of adverse drug reactions in group A was 10. 67%（ 8/75）,and in group B was 34. 67%（ 26/75）,with statistically significant difference（ χ2= 12. 323,P〈 0. 01）. Other severe adverse reactions such as drug allergy and respiratory depression were not found in both groups. Conclusion： The postoperative analgesia effects of diclofenac sodium suppository for postoperative analgesia has no difference compared with tramadol injection,but with fewer adverse drug reactions and easier usage.

关 键 词：双氯芬酸钠栓剂 曲马多针剂 术后镇痛 儿童 

分 类 号：R726.8[医药卫生—儿科]