胱抑素C与老年2型糖尿病患者认知功能障碍的关系  

Relationship between Cystatin C and Cognitive Dysfunction in Elderly Patients with Type 2 Diabetes Mellitus

作　　者：黄迪迪[1] 陈露文[1] 王新洁 覃苑 HUANG Di-di;CHENLu-wen;WANG Xin-jie;et al(Geriatrics Endocrine Metabolism Ward, The People＇s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China)

机构地区：[1]广西壮族自治区人民医院老年内分泌代谢病房,广西南宁530021

出　　处：《医学临床研究》2018年第6期1050-1052,1055,共4页Journal of Clinical Research

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z2015328）

摘　　要：【目的】探讨血清胱抑素C（cystatinC，CysC）与老年2型糖尿病患者认知功能障碍的关系。【方法】选取老年2型糖尿病患者10。例，根据CysC水平分为高CysC组、低CysC组，比较两组各l临床特征及老年认知功能量表（scale of elderly cognitive function，SECF）得分的差异。采用Logistic回归分析CysC与认知功能障碍的相关性。【结果】两组SECF总分及其分项定向力、广度、动物名、计算、分类、临摹、言语、识记的评分差异均有统计学意义（P〈0．05）；在各项目异常病例数比率的比较中，总分、定向力、动物名、计算、临摹、言语的差异均有统计学意义（P〈0．05）；单因素Logistic回归分析发现，与低CysC组相比，高CysC组出现认知功能异常的0R值为2．538，但经多因素Logistic回归分析显示年龄、男性、尿酸是发生认知功能损害的独立危险因素，CysC未进入方程。【结论】血清CysC水平可能与老年2型糖尿病患者认知领域功能障碍相关，但并未独立相关。[Objective]To investigate the relationship between serum cystatin C（Cys C） level and cognitive im- pairment in elderly patients with Type 2 Diabetes Mellitus. [Methods]A total of 100 elderly patients with type 2 diabetes were selected and divided into the high Cys C group and low Cys C group according to their levels of cysta- tin C. The differences of clinical characteristics and the scale of elderly cognitive function （SECF） scores between the two groups were compared. Logistic regression was used to analyze the correlation between the level of Cys C and cognitive dysfunction. [Results]There were statistically significant differences between the two groups in the total score of SECF and its subdivisions： orientation, width, animal name, calculation, classification, copying, speech and memorization （ P〈0.05）. Comparing the ratio of abnormal case numbers in each item, the differences in total score, orientation, memorization, animal name, calculation, copying and speech were statistically signifi- cantly different （ P〈0.05）. Univariate logistic regression analysis showed that the OR value of cognitive dysfunc- tion in high Cys C group was 2.538 compared with that in low Cys C group. However, multivariate logistic regres- sion analysis showed age, male, uric acid were independent risk factors for cognitive impairment; Cys C did not enter the equation. [Conclusion] The level of serum Cys C may be associated with cognitive dysfunction in elderly patients with type 2 diabetes, but is not independently related.

关 键 词：半胱氨酸蛋白酶抑制剂 糖尿病 2型/并发症 认知障碍/并发症 老年人 

分 类 号：R587.1[医药卫生—内分泌]