基于天然小分子化合物的超分子手性自组装  

Supramolecular Chiral Self-Assembly Based on Small Molecular Natural Products

作　　者：高玉霞 梁云 胡君 巨勇[1] Yuxia Gao;Yun Liang;Jun Hu;Yong Ju(Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China;College of Science, China Agricultural University, Beijing 100094, China;Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China)

机构地区：[1]清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京100084 [2]中国农业大学理学院,北京100094 [3]北京化工大学软物质科学与工程高精尖创新中心,北京100029

出　　处：《化学进展》2018年第6期737-752,共16页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21472108;21604085;21772112);国家重点研发计划(No.2017YFD0200302);吉林省青年科研基金项目(No.20160520135JH)资助~~

摘　　要：超分子手性普遍存在于自然界和生命体内,可通过分子在非共价键作用下有序排列形成,对生命科学、药物化学及材料科学的发展起着重要的作用。天然产物来源广泛,具有独特的立体结构和多手性中心,由于其分子手性可以在组装过程中随着分子的有序堆积得到传递和放大,形成超分子手性结构,因此是一类优良的超分子手性构筑基元。研究天然产物的手性自组装,不仅可以拓展其在超分子化学中的应用,还能深化人们对自然界和生命体中手性现象的理解。本文总结了近年来甾体、三萜、氨基酸、糖等天然产物小分子化合物在超分子手性自组装方面的研究进展及其未来的发展前景。Supramolecular chirality,one of the most fascinating phenomena in nature and life,can be generated from orderly molecular self-assembly under non-covalent interactions,and plays an important role in life science,pharmaceutical chemistry,and materials science. Natural products,which are abundant in nature,have attracted immense attention in supramolecular chirality due to their unique stereostructures and multiple chiral centers. By transferring and magnifying the molecular chirality into supramolecular assemblies,natural products have been regarded as one of the ideal building blocks in fabricating supramolecular chiral nanostructures. The study of chiral assembly behavior of natural products will not only expand their applications in supramolecular chemistry,but also help us better understand the chiral phenomena in nature and life. In this review,recent developments of supramolecular chiral self-assembly based on small molecular natural products,such as steroids,triterpenoids,amino acids,sugars,and so on,are summarized and their prospects are discussed.

关 键 词：天然小分子化合物 手性 自组装 非共价键作用 

分 类 号：O641.3[理学—物理化学] O629[理学—化学]