醋酸氯己定洗液抑菌效果及安全性评价  

Evaluation of bacteriostatic effects and safety of chlorhexidine acetate lotion

作　　者：冷静[1] 徐庆华 蔡标[1] 王超[1] 朱倩云[1] 戴陈伟[1] LENG Jing;XU Qing - haa;CA;WANG Chao;ZHU Qian -yun;DAI Cheng -wei(Anhui Academy of Medical Sciences, Hefei 230061, Anhui, China)

机构地区：[1]安徽省医学科学研究院,安徽合肥230061

出　　处：《安徽预防医学杂志》2018年第3期172-174,212,共4页Anhui Journal of Preventive Medicine

基　　金：安徽省"十三五"医疗卫生重点专科建设项目"病原微生物实验室"

摘　　要：目的评价醋酸氯己定洗液的消毒效果和安全性能,为该消毒剂的实际应用提供实验依据。方法采用抑菌试验和动物毒性试验,对该洗液的抑菌效果及安全性进行实验室评价。其中皮肤刺激试验和变态反应试验,受试动物为豚鼠,选择新西兰家兔进行阴道粘膜刺激试验。结果该洗液原液对金黄色葡萄球菌、大肠杆菌、白色念珠菌均有抑制生长作用;对豚鼠皮肤、新西兰家兔阴道黏膜均无刺激性,未见皮肤变态反应。于37℃、相对湿度75%条件下放置3个月后,试验用的醋酸氯己定洗液原液稳定性良好。结论该洗液对试验采用的真菌和细菌具有较好的抑菌效果,稳定性好,对皮肤、黏膜无刺激,可用作皮肤及黏膜消毒。Objective To evaluate the bacteriostatic effects and safety of chlorhexidine acetate lotion,and provide experimental basis for its practical application. Methods The bacteriostatic test and animal toxicity test were used to evaluate the bacteriostatic efficacy and safety of the lotion. Guinea pigs were tested in skin irritation test and allergic reaction test,and New Zealand rabbits were selected for vaginal mucosal stimulation test. Results The solution of the lotion could inhibit the growth of Staphylococcus aureus,Escherichia coli and Candida albicans,and no irritation to the skin of guinea pigs and the vaginal mucosa of New Zealand rabbits and no skin allergy. Stability was good after 3 months at 37℃ and 75%relative humidity. Conclusion The lotion has good bacteriostatic effect on the fungi and bacteria tested,and has good stability,no irritation to skin and mucosa,and can be used for disinfection of skin and mucosa.

关 键 词：醋酸氯己定洗液 抑菌效果 安全性评价 毒理实验 试验研究 

分 类 号：R187[医药卫生—流行病学]