曲美他嗪联合参麦注射液治疗双硫仑样反应所致心肌损伤的效果  

The effects of trimetazidine combined shenmai injection on myocardial injury by disulfiram reaction

作　　者：王瑞[1] 樊颖 李影[1] 张卫国[1] 肖林萍[1] 杨国栋 黄玉霞[1] WANG Rui;FAN Ying;LI Ying;ZHANG Wei-guo;XIAO Lin-ping;YANG Guo-dong;HUANG Yu-xia(Department of Outpatient, No 451 Hospital, PLA, Xi＇an 710054, Shaanxi, China;Department of Outpatient Equipment Academy of Air Force, Beijing 100085, China)

机构地区：[1]解放军451医院门(急)诊部,陕西西安710054 [2]空军研究院门诊部,北京100085

出　　处：《心脏杂志》2018年第4期458-460,共3页Chinese Heart Journal

摘　　要：目的观察曲美他嗪联合参麦注射液治疗双硫仑样反应所致心肌损伤的效果。方法入选与饮酒相关的双硫仑样反应所致心肌损伤患者47例,按入院先后分为常规治疗组(n=24)及曲美他嗪与参麦注射液联合治疗组(联合治疗组,n=23)。观察2组患者入院当时及治疗3 d后心肌标志物[血浆肌红蛋白(Myo)、肌钙蛋白(c Tn)I、肌酸磷酸激酶同工酶(CK-MB)]及超敏C反应蛋白(hs-CRP)、有效率及住院时间并进行比较。结果双硫仑样反应致心肌损伤患病率为7.6%;联合治疗组患者的Myo、c Tn I、CK-MB和hs-CRP均显著低于常规治疗组(均P<0.05)。联合治疗组总有效率(87%)较常规治疗组(46%)显著增高(P<0.01)、住院时间较常规治疗组显著缩短[(43±22)h vs.(86±24)h,P<0.05]。结论曲美他嗪联合参麦注射液治疗双硫仑样反应所致心肌损伤效果优于常规治疗。AIM To observe the effect of trimetazidine combined with shenmai injection on myocardial injury induced by dithiolamlike. METHODS According to admission orders, 47 patients were divided into two groups： a standard therapy group （n=24） and a trimetazidine combined shenmai injection group （n=23）. The standard therapy group accepted routine treatment and the combined therapy group accepted trimetazidine combined shenmai injection based on the conventional treatment. Length of hopitalization, cardiac biomarkers, C-reactive protein levels, electrocardiogram on immedate admission to the hospital and three days after treatment were observed. RESULTS The morbidity rate of myocardial injury by disulfiram reaction was 7.6%. Cardiac biomarkers and C-reactive protein levels were lower, total effective rate were higher ［（87%） vs.（46%）］, length of hopitalization were shorter ［（43±22）h vs.（86±24）h in the combined therapy group than those in the standard therapy group （P〈0.05）］. CONCLUSION The effects of trimetazidine combined shenmai injection on myocardial injury by disulfiram reaction were better than that of conventional therapy.

关 键 词：双硫仑样反应 心肌损伤 曲美他嗪 参麦注射液 

分 类 号：R542.2[医药卫生—心血管疾病]