肠道菌群与子痫前期相关性的研究进展  

Progress in correlation between gut microbiota and preeclampsia

作　　者：赵诚[1] 王伽略[1] 赵扬玉[1] Zhao Cheng;Wang Jialue;Zhao Yangyu.(Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China)

机构地区：[1]北京大学第三医院妇产科,100191

出　　处：《中华围产医学杂志》2018年第7期479-482,共4页Chinese Journal of Perinatal Medicine

基　　金：北京市自然科学基金（S150001）

摘　　要：肠道菌群在人体的代谢和免疫方面发挥着非常重要的调节作用。如果肠道菌群失调，会造成肠黏膜屏障破坏及机体免疫调节异常，从而引起全身炎症反应、氧化应激过度及免疫耐受失衡，在子痫前期的发病过程中，上述因素都发挥着重要的作用。因此，肠道菌群与子痫前期的相关性研究逐渐受到关注，对于揭示子痫前期发病机制提供了新的思路。Gut microbiota plays a very important role in human metabolism and immunity. If intestinal dysbiosis occurs, the intestinal mucosal barrier will be destroyed and the immunoregulation will also be interrupted, resulting in systemic inflammatory response, excessive oxidative stress and unbalanced immune tolerance. All of these may play an important role in the pathogenesis of preeclampsia. Therefore, the correlation between gut microbiota and preeclampsia has attracted increasing attention and is expected to provide new sights for revealing the pathogenesis of preeclampsia.

关 键 词：先兆子痫 胃肠道微生物组 免疫耐受 

分 类 号：R714.244[医药卫生—妇产科学]