钙粒蛋白C与2型糖尿病患者冠心病严重程度的相关性  

Calgranulin C levels are correlated with the presence and severity of coronary artery disease in patients with type 2 diabetes mellitus

作　　者：赵鹏[1] 龚晓亮[1] 王倩梅[1] 尹文[1] ZHAO Peng;GONG Xiaoliang;WANG Qianmei;YIN Wen(Department of Emergency, Xijing Hospital, the Forth Military Medical University, Shaanxi, Xi＇ an, 710032,China)

机构地区：[1]第四军医大学西京医院急诊科,西安710032

出　　处：《临床急诊杂志》2018年第6期384-388,共5页Journal of Clinical Emergency

摘　　要：目的:探讨2型糖尿病患者(T2DM)中血清钙粒蛋白C水平与冠心病(CAD)的发生及严重程度的相关性。方法:选取2016-03—2017-06于我院就诊的168例T2DM患者进行研究,并根据造影结果将其分为糖尿病合并冠心病组(T2DM-CAD组)和糖尿病无冠心病组(T2DM-non-CAD组),以冠状动脉粥样硬化指数(CAI)评价冠心病严重程度,用ELISA方法测定患者血清钙粒蛋白C水平。结果:与T2DM-non-CAD组比较,T2DMCAD组的血清钙粒蛋白C水平明显增高。多变量回归分析显示,钙粒蛋白C水平与CAD发生率独立相关,钙粒蛋白C水平与CAI评分相关。结论:血清钙粒蛋白C与T2DM冠心病的发生及严重程度相关。Objective：We sought to assess whether Calgranulin C levels are correlated with the presence and severity of coronary artery disease（CAD）in patients with type 2 diabetes mellitus（T2 DM）.Method：We recruited 188 consecutive patients with T2 DM who underwent coronary angiography in Xijing Hospital.After coronary angiography,all the patients with T2 DM were classified into patients with and without CAD.The severity of CAD was assessed by the coronary atherosclerosis index（CAI）scores.Serum Calgranulin C levels were determined using ELISA.Result：Calgranulin C levels were significantly higher in patients with T2 DM with CAD than those in patients without CAD.Multivariate Logistic regression analysis revealed that Calgranulin C levels were independently associated with the presence of CAD.Calgranulin C levels were positively correlated with the CAI scores after adjusting for other clinical characteristics.Conclusion：High Calgranulin C levels are associated with the presence and severity of CAD in patients with T2 DM.

关 键 词：钙粒蛋白C 2型糖尿病 冠状动脉粥样硬化指数 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]