Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors  

作　　者：Feng-Juan Yao Ya-Dong Zhang Zi Wan Wei Li Hong Lin Chun-Hua Deng Yan Zhang 

机构地区：[1]Department of Ultrasound, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [2]Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [3]Division of Cardiovascular Rehabilitation, Hear Center, Key Laboratory on Assisted Circulation, Ministry of Health First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

出　　处：《Asian Journal of Andrology》2018年第4期400-404,共5页亚洲男性学杂志（英文版）

摘　　要：This study aimed to gain insight into the underlying pathogenesis of erectile dysfunction in young men under the age of 40 years without widely-known risk factors. Compared with normal controls, patients with erectile dysfunction had increased carotid intima- media thickness, fasting levels of blood glucose and insulin, and homeostatic model assessment index, as well as lower flow-mediated vasodilation and testosterone levels （P 〈 0.05）, though all of these values were within their respective normal range. Multivariate logistic regression analysis identified carotid intima-media thickness, flow-mediated vasodilation, insulin level, and homeostatic model assessment index as significant predictors of erectile dysfunction. Young men with flow-mediated vasodilation 〈10.65% were 11.645 times more likely to have erectile dysfunction, young men with carotid intima-media thickness 〉0.623 mm had a 4.16-fold, and young men with homeostatic model assessment index 〉1.614 had a 5.993-fold greater risk of having erectile dysfunction. In conclusions, in young men with normal results from general clinical screening, an increased carotid intima-media thickness and homeostatic model assessment index and reduced flow-mediated vasodilation were associated with a higher incidence of erectile dysfunction. Erectile dysfunction may appear before the detection of traditional cardiovascular risk factors and may be the earliest clinical sign of subclinical cardiovascular disease.This study aimed to gain insight into the underlying pathogenesis of erectile dysfunction in young men under the age of 40 years without widely-known risk factors. Compared with normal controls, patients with erectile dysfunction had increased carotid intima- media thickness, fasting levels of blood glucose and insulin, and homeostatic model assessment index, as well as lower flow-mediated vasodilation and testosterone levels （P 〈 0.05）, though all of these values were within their respective normal range. Multivariate logistic regression analysis identified carotid intima-media thickness, flow-mediated vasodilation, insulin level, and homeostatic model assessment index as significant predictors of erectile dysfunction. Young men with flow-mediated vasodilation 〈10.65% were 11.645 times more likely to have erectile dysfunction, young men with carotid intima-media thickness 〉0.623 mm had a 4.16-fold, and young men with homeostatic model assessment index 〉1.614 had a 5.993-fold greater risk of having erectile dysfunction. In conclusions, in young men with normal results from general clinical screening, an increased carotid intima-media thickness and homeostatic model assessment index and reduced flow-mediated vasodilation were associated with a higher incidence of erectile dysfunction. Erectile dysfunction may appear before the detection of traditional cardiovascular risk factors and may be the earliest clinical sign of subclinical cardiovascular disease.

关 键 词：endothelial dysfunction erectile dysfunction intima-media thickness risk factors 

分 类 号：S858.292[农业科学—临床兽医学] O351.2[农业科学—兽医学]