-lormone levels following surgical and medical castration： defining optimal androgen suppression  

作　　者：Michael T Schweizer Michael L Hancock Robert H Getzenberg Evan Y Yu 

机构地区：[1]Division of Oncology, Department of Medicine, University of Washington, Seattle WA 98116, USA [2]Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98116, USA [3]Veru Healthcare, Miami, FL 33137, USA

出　　处：《Asian Journal of Andrology》2018年第4期405-406,共2页亚洲男性学杂志（英文版）

摘　　要：Dear Editor, In the 1940s, Charles Huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer, an effect we now understand to be mediated through depriving the androgen receptor （AR） from its ligands （i.e, testicular-derived androgens）.Dear Editor, In the 1940s, Charles Huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer, an effect we now understand to be mediated through depriving the androgen receptor （AR） from its ligands （i.e, testicular-derived androgens）.

分 类 号：Q579.11[生物学—生物化学] TS195.67[轻工技术与工程—纺织化学与染整工程]