Rhododendron Molle(Ericaceae):phytochemistry,pharmacology,and toxicology  

作　　者：CAI Yong-Qing HU Jian-Hui QIN Jie SUN Tao LI Xiao-Li 

机构地区：[1]Department of Pharmacy,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China [2]Student Brigade Ten Team,Second Military Medical University,Shanghai 200433,China [3]Student Eleven Camp,Third Military Medical University,Chongqing 400038,China [4]College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [5]College of Pharmacy,Chongqing Medical University,Chongqing 400016,China [6]Chongqing Key Laboratory of Drug Metabolism,Chongqing 400016,China

出　　处：《Chinese Journal of Natural Medicines》2018年第6期401-410,共10页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81302797);Research Project of Chongqing Science and Technology(No.cstc2015jcyj BX0018);Research Project of Third Military Medical University(No.2015XZH19)

摘　　要：Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, Sci Finder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle.Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, Sci Finder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle.

关 键 词：RHODODENDRON molle PHYTOCHEMISTRY PHARMACOLOGY TOXICOLOGY 

分 类 号：R965[医药卫生—药理学]