SLE患者外周血单核细胞CD36水平与血脂紊乱的关系  

Relationship between CD36 Expression on Peripheral Blood Monocytes and Dyslipidemia in SLE Patients

作　　者：凡瞿明 杜琴[1,2] 卢小岚 王强[3,2] 汪光蓉 王东生[1,2] 蔡艳娟 邓仁兵[1] 刘萍 张国元[1,2] FAN Qu-ming;DU Qin;LU Xiao-lan;WANG Qiang;WANG Guang-rong;WANG Dong sheng;CAI Yan-juan;DENG Ren-bing;LIU Ping;ZHANG Guo-yuan(Department of Clinical Laboratory ,Affiliated Hospital of North Sichuan Medical College, Sichuan Nanchong 637000,China;Faculty of Clinical Laboratory, North Sichuan Medical College, Sichuan Nanchong 637000, China;Translational Medicine Research Center, North Sichuan Medical College, Sichuan Nanchong 637000, China;Bioscience Biotechnology Co. , L TD , Tientsin, Tianj in 300300, China)

机构地区：[1]川北医学院附属医院检验科,四川南充637000 [2]川北医学院转化医学研究中心,四川南充637000 [3]川北医学院检验系,四川南充637000 [4]博奥赛斯天津生物科技有限公司,天津300300

出　　处：《现代检验医学杂志》2018年第3期50-53,共4页Journal of Modern Laboratory Medicine

基　　金：国家科技支撑计划项目;编号:2015BAK45B01

摘　　要：目的通过检测系统性红斑狼疮(systemic lupus erythematosus,SLE)患者及表观健康自愿者外周血单核细胞CD36的表达及其血清脂蛋白水平,探讨SLE患者单核细胞CD36表达对脂代谢的影响,为临床早期提示SLE并发心血管疾病风险提供依据。方法利用流式细胞仪检测SLE患者30例和健康体检者31例外周血单核细胞CD36强度,采用生化仪测定血清脂蛋白水平,统计分析患者与健康对照组间单核细胞CD36表达平均荧光强度与血清脂蛋白浓度差异性,及SLE患者CD36与脂蛋白间的相关性。结果 SLE患者单核细胞CD36表达低于健康对照组(|Z|=4.198,P=0.000),TG,VLDLC和apoB100高于对照组(|Z|=4.603,P=0.000;|Z|=3.620,P=0.001;|Z|=2.208,P=0.027),HDLC与apoA1低于对照组(|Z|=3.751,P=0.000;|Z|=3.918,P=0.000),差异均有统计学意义;TC和LDLC在两组间差异无统计学意义(|Z|=0.159,P=0.874;|Z|=0.476,P=0.634)。SLE患者单核细胞CD36表达强度与血清脂蛋白水平无显著相关性(P>0.05)。结论系统性红斑狼疮患者外周血单核细胞CD36表达相较健康人群降低,其可能是SLE心血管疾病高发的独立风险因素。Objective To explore the relationship between expression level of CD36 on peripheral rnonocytes and dyslipi- dernia ,and evaluate the clinical significance in prediction risk of cardiovascular disease in patients with systemic lupus erythe matosus（SLE）. Methods Monocytes CD36 and serum lipoprotein levels were determined in 30 patients with SLE and 31 ca- ses healthy volunteers. Compared CD36 of rnonocytes expression intensity and lipoprotein concentration in SLE patients and health controls. Meanwhile,the correlation between CD36 and lipoprotein was analyzed in SLE patients. Results The CD36 expression on rnonocytes in patients with SLE was significantly lower than that in the control group （ ｜Z｜ = 4. 198, P ： 0. 000）. TG, VLDLC and apoB100 levels of SLE patients were significantly higher than the control group （｜Z｜ =4. 603, P = 0. 000. ｜Z｜ =3. 620,P=0. 001. ｜Z｜ = 2. 208,P=0. 027）. HDLC and apoA1 levels of SLE patients were significantly lower than the control group （｜Z｜ =3. 751 ,P=0. 000. ｜Z｜ =3. 918,P= 0. 000）. There were no statistically significant difference in TC and LDLC between SLE patients and healthy volunteers （｜Z｜ =0. 159,0. 476,P=0. 874,0. 634）. There was no signif icant correlation between CD36 expression intensity and serum lipoprotein levels in SLE patients （P〉 0.05）. Conclusion The expression of CD36 on peripheral blood rnonocytes of patients with SI.E was lower than that of healthy people,and the decrease of CD36 expression on rnonocytes may be an independent risk factor for cardiovascular disease in SLE.

关 键 词：系统性红斑狼疮 单核细胞 簇分化抗原36 脂蛋白 

分 类 号：R593.241[医药卫生—内科学] R392.11[医药卫生—临床医学]