肠道微生物群在血栓形成及心脑血管疾病中的研究进展  

Research Progress of Gut Microbiota in the Thrombosis Formation and Cerebro-Cardiovascular Disease

作　　者：曹杨琳 杨剑峰[1] 何杨[1] CAO Yang-lin;YANG Jian-feng;HE Yang(the First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology ,Jiangsu Suzhou 215006 ,China)

机构地区：[1]苏州大学附属第一医院,江苏省血液研究所,江苏苏州215006

出　　处：《现代检验医学杂志》2018年第3期162-164,共3页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金(81773356,81673096,81700129);江苏省自然科学基金(BK20171204)

摘　　要：心脑血管疾病作为临床常见病,具有高发病率、高致残率及高死亡率的特点。研究认为血小板黏附、活化及聚集引起的血管内血栓是导致心脑血管疾病发生的重要原因之一,因此,探索和明确有关血小板活化及血栓形成的因素是预防和控制心脑血管疾病的重要切入点。最近的研究显示肠道微生物群作为人体内最大最复杂的微生态系统参与到血小板功能的调控中。笔者对肠道微生物群参与血栓形成及作为血栓性疾病治疗手段的最新进展进行综述,从而为肠道微生物群为基础的治疗方案在心脑血管疾病中的临床应用提供新的思路和理论依据。Cerebro-cardiovascular disease which is common in clinical practice is featured by its high incidence,morbidity and mortality. So studies have shown that adhesion,activation and aggregation of the platelets and thrombosis induced by plate- lets are considered to play a critical role in the pathogenesis of cerebro-cardiovascular disease, therefore, exploration and iden- tification of the factors involved in the platelet activation and thrombosis formation is an important incision for prevention and control of cerebr^cardiovascular disease. Recent studies have suggested that gut microbiota, as the most largest and complicated micro-ecosystem in human body,is participated in the platelet function regulation. Here,author reviewed the re- cent progress about the role of gut microbiota in thrombosis formation and its therapeutic potential, and these data are be- lieved to provide novel insight and theory basis for application of gut microbiota-base treatment regimen in the cerebro-cardi- ovascular diseases.

关 键 词：心脑血管病 肠道微生物群 血小板 血栓 

分 类 号：R54[医药卫生—心血管疾病] R446.5[医药卫生—内科学]