FK1706促进外周神经旁路移植术后大鼠神经再生的研究  

Study on Effect of FK1706 to Accelerate Neuroregeneration after Nerve Bypass Grafting Surgery

作　　者：肖毓华 徐杰[1] 李鋆 XIAO Yuhua;XU Jie;LI Jun(Fnjian Provincial Hospital,Fuzhou350001,China)

机构地区：[1]福建省立医院,福建福州350001 [2]福建医科大学省立临床医学院

出　　处：《中国医学创新》2018年第13期23-26,共4页Medical Innovation of China

基　　金：福建省卫生系统中青年骨干人才培养项目(2013-ZQN-ZD-1)

摘　　要：目的:探究在大鼠神经旁路移植术后应用FK1706对促进神经再生的作用。方法:SD雄性成年大鼠20只,随机分成两组,每组10只,行左坐骨神经开窗离断-自体桡神经旁路移植术。实验组(FK1706组)术后即日开始连续8周左下肢局部肌注FK1706(0.32 mg/kg),对照组做空白对照。8周后行左侧坐骨神经电生理监测、左腓肠肌肌肉湿重及肌纤维横截面积测定。结果:8周后,实验组的CAMP波幅高于对照组,MNCV快于对照组,差异均有统计学意义(P<0.01)。实验组的腓肠肌湿重及肌纤维面积均高于对照组,差异均有统计学意义(P<0.05)。两组的近端有髓神经纤维数比较,差异无统计学意义(P>0.05),实验组远端有髓神经纤维数、纤维横截面积均明显优于对照组,差异均有统计学意义(P<0.01)。结论:大鼠神经旁路移植术后应用FK1706能够移植神经再生。Objective：To investigate the effects of FK1706 to neuroregeneration after nerve bypass grafting.Method：20 adult male SD rats were randomly divided into two groups,10 cases in each group,the left sciatic nerve fenestration and autologous radial nerve bypass grafting was performed.In the experimental group,FK1706（0.32 mg/kg） was injected into the left lower extremities for 8 weeks immediately after the operation,the control group was made blank control.After 8 weeks,the electrophysiological monitoring of the left sciatic nerve,the wet weight of the left gastrocnemius muscle and the cross section of the muscle fiber were measured.Result：After 8 weeks,the amplitude of CAMP in the experimental group was higher than that in the control group,MNCV was faster than that of control group,the differences were statistically significant（P〈0.01）.The wet weight and fiber area of gastrocnemius in the experimental group were higher than those in the control group（P〈0.05）.There was no significant difference in the number of myelinated nerve fibers between the two groups（P〈0.05）,the number and cross-sectional area of distal myelinated nerve fibers in the experimental group were significantly better than those in the control group,the differences were statistically significant（P〈0.01）.Conclusion：The effects of FK1706 to accelerate neuroregeneration after nerve bypass grafting surgery is siginicant.

关 键 词：FK1706 自体神经移植 神经再生 

分 类 号：R651.3[医药卫生—外科学]