妊娠期高血压疾病患者尿蛋白成分与妊娠结局的关系  

Relationship between Urinary Protein Components and Pregnancy Outcome in Patients with Hypertensive Disorder Complicating Pregnancy

作　　者：邓艳君[1] 梁志冬 许宝莹 贾金平[1] 秦江霞[1] DENG Yanjun;LIANG Zhidong;XU Baoying(Huadu District Maternal and Child Health Care Hospital,Guangzhou 510800,China)

机构地区：[1]广州市花都区妇幼保健院,广东广州510800

出　　处：《中国医学创新》2018年第12期58-61,共4页Medical Innovation of China

基　　金：广州市花都区科技计划项目(16-HDWS-042)

摘　　要：目的:探讨妊娠期高血压疾病患者尿蛋白成分与妊娠结局的关系。方法:回顾性分析2015年5月-2016年12月本院门诊产检的孕产妇的临床资料,选取出现妊娠期高血压疾病和蛋白尿的产妇120例为研究组,按照第一次监测出高血压的时间分为A组(<12周)、B组(12~28周)和C组(>28周),各40例;同期选取正常孕妇40例为对照组。比较四组入院准备分娩时尿液中蛋白成分;比较四组孕妇分娩结局和围生儿不良结局。结果:四组尿蛋白成分比较差异有统计学意义(X^2=45.144,P=0.000);四组剖宫产、ICP、胎盘早剥、羊水过多和产后出血比较,差异均有统计学意义(P<0.05);四组死胎、早产、低出生体重儿及胎儿宫内窘迫比较,差异均有统计学意义(P<0.05);剖宫产比例越高,出现ICP、胎盘早剥、羊水过多和产后出血比例越大,围生儿不良结局比例越高。结论:妊娠期高血压疾病出现时间越早的产妇,尿蛋白中大分子蛋白质含量越高,产妇和新生儿结局越差,提早对妊娠期高血压产妇的干预和监控,必要时可结束妊娠来减少围生期不良结局的出现。Objective：To investigate the relationship between urinary protein components and pregnancy outcome in patients with hypertensive disorder complicating pregnancy.Method：The clinical data of pregnant women in our hospital from May 2015 to December 2016 were retrospectively analyzed,120 pregnant women with hypertension and proteinuria were selected as study group,according to the first monitoring of the time of hypertension,they were divided into A group（12 weeks）,B group（12-28 weeks） and C group（28 weeks）,40 cases in each group,and 40 cases of normal pregnant women in the same period were selected as control group.The urinary protein components in four groups at admission for delivery were compared,the outcomes of delivery and perinatal adverse outcomes in four groups were compared.Result：The urine protein components in four groups were compared,the difference was statistically significant（ χ^2=45.144,P=0.000）.The cesarean section,ICP,placentalabruption,amniotic fluid and postpartum hemorrhagein of four groups were compared,the differences were statistically significant（P〈0.05）.The fetal death,premature delivery,low birth weight infants and intrauterine fetal distress in four groups were compared,the differences were statistically significant（P〈0.05）.The higher proportion of cesarean section,ICP,placental abruption,amniotic fluid excess and postpartum hemorrhage,the higher the proportion of perinatal adverse outcome.Conclusion：The higher the time of onset of hypertensive disorder complicating pregnancy,the higher the content of large molecular protein in urine protein,the worse the maternal and neonatal outcomes,the intervention and monitoring of maternal hypertension should be early,if necessary,the pregnancy can be terminated to reduce the occurrence of perinatal adverse outcomes.

关 键 词：妊娠期高血压疾病 尿蛋白 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]