血清脂蛋白a水平与心血管疾病的关系  

Relationship between Serum Lipoprotein a Level and Cardiovascular Disease

作　　者：刘敬峰 汪顺银[2] LIU Jingfeng;WANG Shunyin(Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学,广东湛江524001 [2]广东省佛山市第二人民医院

出　　处：《中国医学创新》2018年第11期139-143,共5页Medical Innovation of China

摘　　要：血清脂蛋白(a)由低密度脂蛋白样微粒和载脂蛋白(a)构成,已有大量研究提示,脂蛋白(a)与心血管疾病的发生密切相关,它可能使冠心病、主动脉瓣狭窄等的发生率提高,并且脂蛋白(a)可能与心力衰竭的发生亦有相关性。然而,人群脂蛋白(a)浓度主要由遗传因素决定,目前仍缺乏高效安全降低脂蛋白(a)水平的治疗方法。近年来研究提示血脂净化技术等可有效降低高脂蛋白(a)的心血管事件发生率,但用于临床治疗还需进一步研究。本文拟对近年来脂蛋白(a)与心血管疾病研究的新进展进行综述。Serum lipoprotein（a） consists of low-density lipoprotein-like particles and apolipoprotein（a）,there are a large number of studies that suggest that lipoprotein（a） is closely related to the occurrence of cardiovascular diseases and may increase incidence of coronary heart disease,aortic stenosis and so on,and lipoprotein（a） may also be associated with the occurrence of heart failure.However,the population of lipoprotein（a） concentration is mainly determined by genetic factors, the current lack of efficient and safe reduction of lipoprotein（a） levels of treatment.In recent years,studies suggest that blood lipids purification technology can effectively reduce the incidence of cardiovascular events of high-fat protein（a）,however,for clinical treatment needs further study.This article reviews the recent advances in the study of lipoprotein（a） and cardiovascular diseases.

关 键 词：脂蛋白(a) 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]