美罗培南治疗神经外科手术后颅内感染的可行性分析  

The feasibility of the treatment of intracranial infection after neurosurgery

作　　者：万兴[1] 陈云祥 杨帆[1] 周格知[1] 刘继红[1] 童民峰 Wan Xing;Chen Yunxiang;Yang Fan;Zhou Gezhi;Liu Jihong;Tong Minfeng(Department of Neurosurgery,Zhejiang jinhua central hospital,Jinhua,Zhejiang,321000,China)

机构地区：[1]浙江省金华市中心医院神经外科,浙江金华321000

出　　处：《当代医学》2018年第17期17-19,共3页Contemporary Medicine

摘　　要：目的分析美罗培南治疗神经外科手术后颅内感染的可行性。方法选择2016年5月~2017年5月本院收治的50例接受神经外科手术后颅内感染者为研究对象,按照治疗方案不同,分为对照组以及观察组,每组25例。对照组接受腰大池持续外引流+万古霉素静滴治疗,以此为基础,观察组加用美罗培南,分析治疗效果。结果对照组治疗有效率为72.00%,观察组为96.00%,和对照组相比,观察组治疗有效率明显较高,差异具有统计学意义(P<0.05),和对照组相比,观察组治疗后脑脊液蛋白质、白细胞数量以及葡萄糖水平更接近正常值,差异具有统计学意义(P<0.05)。结论对于经神经外科手术后发生颅内感染的患者,使用美罗培南治疗,安全性强,可有效改善实验室指标,值得进一步在临床中推广使用。Objective To analyze the feasibility of the treatment of intracranial infection after neurosurgery. Methods In May 2016-May 2017 in our hospital of 50 cases of intracranial infection after neurosurgical surgery as the research object, according to the different treatment, were divided into control group and observation group, 25 cases in each group. The control group was treated with continuous external drainage and vancomycin hydrostatic drop treatment in the lumbar cisterna, which was based on the observation group plus meropenem to analyze the therapeutic effect.Results The control group, the treatment effective rate was 72.00%, observation group was 96.00%, compared with control group, the treatment efficient observation group was obviously higher, the difference was statistically significant（P〈0.05）. Compared with control group, the observation group after treatment of cerebrospinal fluid protein, and blood glucose levels closer to normal, the difference was statistically significant（P〈0.05）.Conclusion The occurrence of intracranial infection after neurosurgery patients, using Meropenem treatment, strong security, which can effectively improving laboratory index, worthy of further promotion in clinical use.

关 键 词：美罗培南 神经外科 术后颅内感染 

分 类 号：R651[医药卫生—外科学]