依托孕烯皮下埋置剂的临床应用  

Clinical application of a subdermal etonogestrel implant

作　　者：郭李璐 周燕飞[1] 丁虹[1] 王晓兰[1] Guo Lilu;Zhou Yanfei;Ding Hong;Wang Xiaolan(Family Planning Section,Changsha Maternal and Child Health Hospital,Changsha,Hunan,410007,China)

机构地区：[1]长沙市妇幼保健院计划生育科,湖南长沙410007

出　　处：《当代医学》2018年第17期33-35,共3页Contemporary Medicine

摘　　要：目的观察新型的单根型依托孕烯皮下埋置剂植入后的临床应用情况及使用者的接受程度。方法纳入200例有避孕需求的妇女,包括20例哺乳期女性,在知情理解的情况下签署手术同意书后植入皮下埋植避孕剂,以90天为1个观察期,观察使用者的适应情况、出血模式改变、避孕效果、体质量变化、哺乳情况及其他不良反应。对要求取出皮埋剂使用者统计其取出原因。对持续使用皮埋剂1年的76例使用者,检测她们1年期间的体质量变化。结果各观察期内出血模式改变主要为闭经。哺乳期女性植入皮埋剂后喂奶次数无改变,监测婴儿生长发育正常。观察期间有效避孕率达100%。使用者植入皮埋剂1年前,平均体质量为(54.31±9.03)kg,使用1年皮埋剂后平均体质量为(54.64±8.31)kg。2年18%的使用者要求取出皮埋,阴道出血不规则占取出原因的47.22%。结论依托孕烯皮下埋置剂主要副作用为出血模式改变,最常见的出血模式为闭经。植入后对体质量无明显影响,不影响哺乳期乳汁的产生及婴儿生长发育,避孕效果好。使用者要求取出皮埋的主要原因为阴道不规则出血。Objective To observe the clinical application and user acceptance of a new type of single rod etonogestrel contraceptive implant.Methods 200 women with contraceptive requirement were included. Including 20 lactating women, under the condition of informed understanding,signed the consent to the operation and then implanted a subcutaneous implant, using 90 days as an observation period, to observe the adaptation of users, bleeding pattern changes. Contraceptive effect, weight change, lactation condition and other adverse reactions. The reasons for early removals were counted. 76 subjects who continued to use subdermal implant for one year, detected the changes in weight and bleeding patterns during their 1-year period. Results The main changes of bleeding pattern in each observation period were amenorrhea. The feeding times of breast-feeding women did not change after implantation of a subcutaneous implant, the growth and development of infants were normal. 100% efficiency of contraceptive during the observation period with etonogestrel contraceptive implant. The average body weight was（54.31±9.03）kg before implantation of subcutaneous implants, after one year the average body weight was（54.64±8.31）kg. The proportion of remove the implant was 18% during 2 year. Irregular vaginal bleeding accounted for 47.22% of the reasons. Conclusion The main side effect of etonogestrel contraceptive implant is the change of bleeding pattern, and the most common bleeding pattern is amenorrhea. There was no significant effect on body weight after implantation, and no effect on milk production and infant growth during lactation. The contraceptive efficacy was satisfied. Irregular vaginal bleeding is the main cause of the user＇s request to remove the subcutaneous implants.

关 键 词：皮下埋置剂 依托孕烯 出血模式 避孕 不良反应 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]