Urine glucose levels are disordered before blood glucose level increase was observed in Zucker diabetic fatty rats  

作　　者：Wei Yin Weiwei Qin Youhe Gao 

机构地区：[1]Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine,Peking Union Medical College [2]Department of Biochemistry and Molecular Biology, College of Life Science, Beijing Normal University, Gene Engineering and Biotechnology Beijing Key Laboratory

出　　处：《Science China(Life Sciences)》2018年第7期844-848,共5页中国科学（生命科学英文版）

基　　金：supported by the National Key R&D Program of China (2016YFC1306300);the National Basic Research Program of China (2013CB530805);the Beijing Natural Science Foundation (7173264, 7172076);the Fundamental Research Funds for the Central Universities (2015KJJCB21);the Beijing cooperative construction project(110651103);Beijing Normal University (11100704)

摘　　要：Many patients with diabetes are not diagnosed at all or are diagnosed too late to be effectively treated, resulting in nonspecific symptoms and a long period of incubation of the disease. Pre-diabetes is an early warning signal of diabetes, and the change of urine glucose in this period has been ignored even though urine has long been related with diabetes. In this study, Zucker diabetic fatty (ZDF) rats were used to test if there were changes in urine glucose before blood glucose increases. Six 8-week-old male ZDF rats (fa/fa) and Zucker lean (ZL) rats (fa/+) were fed with Purina 5008 high-fat diet and tested for fasting blood glucose and urine glucose. After 12 weeks of feeding, the urine glucose values of the ZL rats were normal (0–10 mmol L^(-1)), but the values of the ZDF model rats increased 10 weeks before their blood glucose levels elevated. The urine glucose values of the ZDF model rats showed a state of disorder that was frequently elevated (>10 mmol L^(-1)) and occasionally normal (0–10 mmol L^(-1)). This finding may provide an easy early screening for diabetes by long-term monitoring of urine glucose levels: pre-diabetes may be revealed by frequently disordered urine glucose levels over a period.Many patients with diabetes are not diagnosed at all or are diagnosed too late to be effectively treated, resulting in nonspecific symptoms and a long period of incubation of the disease. Pre-diabetes is an early warning signal of diabetes, and the change of urine glucose in this period has been ignored even though urine has long been related with diabetes. In this study, Zucker diabetic fatty （ZDF） rats were used to test if there were changes in urine glucose before blood glucose increases. Six 8-week-old male ZDF rats （fa/fa） and Zucker lean （ZL） rats （fa/＋） were fed with Purina 5008 high-fat diet and tested for fasting blood glucose and urine glucose. After 12 weeks of feeding, the urine glucose values of the ZL rats were normal （0-10 mmol L^（-1））, but the values of the ZDF model rats increased 10 weeks before their blood glucose levels elevated. The urine glucose values of the ZDF model rats showed a state of disorder that was frequently elevated （〉10 mmol L^（-1）） and occasionally normal （0-10 mmol L^（-1））. This finding may provide an easy early screening for diabetes by long-term monitoring of urine glucose levels： pre-diabetes may be revealed by frequently disordered urine glucose levels over a period.

关 键 词：type 2 diabetes mellitus urine glucose ZDF rats impaired glucose regulation PRE-DIABETES 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]