β2-微球蛋白、D-二聚体、纤维蛋白原降解产物联合检测对急性早幼粒细胞白血病诊断及病情观察的临床意义  

Clinical Significance of Combined Detection of β2-microglobulin, D-dimer and Fibrinogen Degradation Product in Diagnosis and Observation of Acute Promyelocytic Leukemia

作　　者：宋慧娟[1] 张卫军[1] 牟锐[1] 冷颖浩 于涛 李明君 刘克宇[2] SONG Hui-juan;ZHANG Wei-jun;MU Rui;LENG Ying-hao;YU Tao;LI Ming-jun;LIU Ke-yu(Dalian University Affiliated Zhongshan Hospital, Dalian Liaoning 116001;Hebei University of Engineering Affiliated Hospital , Handan Hebei 056002)

机构地区：[1]大连大学附属中山医院,辽宁大连116001 [2]河北工程大学附属医院,河北邯郸056002

出　　处：《世界最新医学信息文摘》2018年第15期13-13,15,共2页World Latest Medicine Information Electronic Version

摘　　要：目的观察血清β2微球蛋白(β2-MG)、血浆D-二聚体(D-D)、纤维蛋白原降解产物(FDP)水平在急性早幼粒细胞白血病(APL)中的变化,探讨其对APL患者诊断及疗效判断的临床意义。方法选取53例APL患者及50例健康体检者,分别用乳胶增强免疫比浊法及免疫比浊法检测APL患者治疗前(初诊组)、完全缓解组(CR组)血清β2-MG、血浆D-D、FDP水平,并与50例对照组比较分析。结果 (1)APL初诊组血清β2-MG、血浆D-D、及FDP水平均显著高于完全缓解组及对照组,差异具有统计学意义(P<0.05),完全缓解组及对照组血清β2-MG、血浆D-D、FDP水平比较,差异无统计学意义(P>0.05)。(2)APL初诊组血浆D-D与FDP水平呈正相关(r=0.793,P<0.05)。结论血清β2-MG、血浆D-D及FDP联合检测对APL诊断及疗效判断有一定的临床意义。Objective to observe changes of serum 2 microglobulin（β2-MG）, plasma D-dimer（D-D） and fibrinogen degradation product（FDP） level of acute promyelocytic leukemia（APL）, and to explore its clinical significance in diagnosis and curative effect estimation of APL patients. Methods choose 53 cases APL patients and 50 cases healthy checkup people, detect serumβ2-MG, plasma D-D and FDP level of first visit group（before treatment）, complete remission group（CR group） by latex enhanced immunoturbidimetry and routine immunoturbidimetry. Compare them with 50 cases in control group. Results（1） serum β2-MG, plasma D-D and FDP level of first visit group was significantly higher than complete remission group and control group, difference showed statistical significance,（P〈0.05）,serum β2-MG, plasma D-D, FDP level difference of complete remission group and control group showed no statistical significance,（P〉0.05）.（2） plasma D-D of first vist group was positive correlated with and FDP level,（r=0.793, P〈0.05）. Conclusion combined detection of serum β2-MG, plasma D-D and FDP has some certain clinical significance for APL diagnosis and curative effect estimation.

关 键 词：急性早幼粒细胞白血病 血清Β2-微球蛋白 血浆D-二聚体 纤维蛋白原降解产物 

分 类 号：R457.2[医药卫生—治疗学]