基于葡萄糖转运体的中药调控2型糖尿病胰岛素抵抗研究新进展  

Research Progress on The Mechanism-based on Glucose Transporter Chinese Herbal Treatment for Insulin Resistance in Type 2 Diabetes Mellitus

作　　者：李斌[1] 李鑫[2] 范源[1] LI Bin;LI Xin;FAN Yuan(Schools of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 550200,China;Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]云南中医学院中药学院,昆明650200 [2]湖南中医药大学中医诊断学湖南省重点实验室,长沙410007

出　　处：《中国中医基础医学杂志》2018年第6期863-866,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：胰岛素抵抗是2型糖尿病的主要病理机制之一,主要表现为肝脏、骨骼肌以及脂肪等胰岛素敏感的靶组织对葡萄糖的摄取和利用障碍。研究表明,葡萄糖转运体蛋白是胰岛素信号传导通路的重要靶蛋白,参与组织细胞对葡萄糖的利用。本文主要从中药及其复方通过多途径、多靶点促进葡萄糖转运体的易位及其基因表达而改善2型糖尿病胰岛素抵抗研究新进展进行综述,以期为2型糖尿病的防治提供新思路。Insulin resistance is one of the main pathophysiological mechanism of type 2 diabetes mellitus,which mainly occurs in the liver,skeletal muscle,fat and other insulin sensitive target tissue for glucose uptake and utilization disorder. The research finds that the glucose transporter protein is the medium for the insulin signal transduction pathway to stimulate cells to glucose utilization. This paper reviews that the traditional Chinese medicine and its formulation through a variety of ways to promote glucose transporter protein translocation and（or） glucose transporter gene expression to improve the IR in type 2 diabetes mellitus.

关 键 词：中药 2型糖尿病 胰岛素抵抗 葡萄糖转运体 

分 类 号：R587[医药卫生—内分泌]