一锅法合成3,5-二氯-2-戊酮  

Preparation of 3,5-Dichloro-2-pentanone inan One-pot Process

作　　者：曾敬 曾雪云 刘民华 刘伟 王胜得[1,2] 陈明 黄明智 ZENG Jin;ZENG Xue-yun;LIU Min-hua;LIU Wei;WANG Sheng-de;CHEN Ming;HUANG Ming-zhi(National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry Co., Ltd., Changsha 510014, China;Hunan Province Key Laboratory for Agrochemicals, Changsha 410015, China;Institute of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China)

机构地区：[1]湖南化工研究院有限公司国家农药创制工程技术研究中心,湖南长沙410014 [2]农用化学品湖南省重点实验室,湖南长沙410014 [3]湖南大学化学化工学院,湖南长沙410082

出　　处：《精细化工中间体》2018年第2期19-21,共3页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(21672057);湖南省自然科学基金资助项目(2016JJ2047)

摘　　要：以α-乙酰基-γ-丁内酯为起始原料,经氯化、氮气置换、溶剂回收、水解开环、脱羧和亲核氯代一锅法合成了3,5-二氯-2-戊酮,并优化了工艺条件,改进了后处理方法。目标化合物总收率达70.5%(以α-乙酰基-γ-丁内酯计),产品含量95.5%。其结构经GC-MS、~1H NMR确认。3,5-Dichloro-2-pentanone was prepared in an one-pot process including chlorination, nitrogen replaceable,solvent recovery, hydrolytic ring-opening, decarboxylation and nucleophilic substitution using α-acetyl-γ-butyrolactone as the starting material. The reaction conditions and post-treatment were optimized. Under optimal condition, the target compound was obtained with a purity of more than 95.5%（by α-acetyl-γ-butyrolactone） and a yield of more than 70.5%.And its structure was confirmed by GC-MS and -1H NMR.

关 键 词：3 5-二氯-2-戊酮 α-乙酰基-α-氯-γ-丁内酯 一锅法 α-乙酰基-γ-丁内酯 

分 类 号：S482.2[农业科学—农药学]