N-甲氧基-N-(2-甲基)苯基氨基甲酸甲酯的合成研究  

Synthesis of Methyl N-Methoxy-N-(2-methyl)phenylcarbamate

作　　者：王兴飞 董鹏 王庆海 裘志炜 王鹤锦 薛成辉 丁成荣[1] WANG Xing-fei;DONG Pen;WANG Qing-hai;QIU Zhi-wei;WANG He-jing;XUE Cheng-hui;DING Cheng-rong(College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;Zhejiang Huahai Pharmaceutical Co., Ltd., Linhai 317016, China)

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014 [2]浙江华海药业股份有限公司,浙江临海317016

出　　处：《精细化工中间体》2018年第2期24-26,共3页Fine Chemical Intermediates

基　　金：浙江省大学生科技创新活动计划(新苗人才计划)资助

摘　　要：以邻硝基甲苯为起始原料经N-酰基化、O-甲基化合成N-甲氧基-N-(2-甲基)苯基氨基甲酸甲酯,反应总收率达76.3%(以邻硝基甲苯计),产品结构经核磁共振氢谱及质谱确认。该工艺具有反应条件温和,操作简单,产品收率高等优点,适合工业化生产。Phenylcarbamate was synthesized using O-nitrotoluene as the starting material through a series of reactions including nitro reduction, N-acylation and O-methylation reaction. Under the optimal conditions, the total yield was 76.3% based on o-nitrotoluene. And the structure of the prepared product was confirmed by -1H NMR and MS.The experimental results showed that the process exhibited mild reaction conditions, simple operation, high yield,and was suitable for industrial production.

关 键 词：N-甲氧基-N-(2-甲基)苯基氨基甲酸甲酯 唑菌胺酯 邻硝基甲苯 合成工艺 

分 类 号：O625.6[理学—有机化学]