氨基二茂铁的合成研究  

Synthesis of Aminoferrocene

作　　者：范钢[1] 高浩凌 沈大冬[1] FAN Gang;GAO Hao-ling;SHEN Da-dong(Research ＆ Development Center, Zhejiang Pharmaceutical Co., Ltd.,Shaoxing 312500, China)

机构地区：[1]浙江医药股份有限公司研究院,浙江绍兴312500

出　　处：《精细化工中间体》2018年第2期30-32,共3页Fine Chemical Intermediates

摘　　要：以二茂铁甲酸为原料,与叠氮磷酸二苯酯的叔丁醇溶液反应生成中间体N-Boc氨基二茂铁(3),然后用三氟乙酸脱保护合成氨基二茂铁(1),总收率68.1%,其结构经~1H NMR确证。The intermediate of tert-butyl ferrocenylcarbamate（3） was synthesized from a reaction between tert-butanol solution of diphenylphosphoryl azide and ferrocenecarboxylic acid. And aminoferrocene（1） was obtained followed by deprotection in two steps with trifluoroacetic acid, the total yield was 68.1%. The structure was confirmed by -1H NMR.

关 键 词：氨基二茂铁 中间体 合成 

分 类 号：O625.6[理学—有机化学]