Yb(OTf)_3催化Hantzsch反应合成氢化喹啉羧酸酯衍生物  

Synthesis of Hydroquinoline Derivatives via Hantzsch Reaction Catalyzed by Yb(OTf)_3

作　　者：谭伟强[1] 黄楠楠 赵峰 TAN Wei-qiang;HUA NG Nan-nan;ZHA O Feng(Research Center of Environmental Biology and Green Chemistry, School of Environmental and Municipal Engineering, Qingdao Technological University, Qingdao 266033, Chin)

机构地区：[1]青岛理工大学环境与市政工程学院生物环保与绿色化工研究中心,山东青岛266033

出　　处：《精细化工中间体》2018年第2期36-38,共3页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(21102079);山东省自然科学基金资助项目(ZR2010BQ015)

摘　　要：以稀土化合物Yb(OTf)_3催化的双甲酮、对硝基苯甲醛和乙酰乙酸环己酯的Hantzsch反应,"一锅法"合成了环己基1,4,5,6,7,8-六氢-2,7,7-三甲基-4-(4-硝基苯基)-5-氧代-3-喹啉羧酸酯。该方法操作简单、条件温和、收率较高,产物结构经核磁共振和液质进行分析表征。The one-pot Hantzsch reaction from diketone, 4-nitrobenzaldehyde and cyclohexyl 3-oxobutanoate catalyzed by Yb（OTf）3 afforded the cyclohexyl 4-（4-nitrophenyl）-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate in high yield under mild condition. All structures were confirmed by -1H NMR and LC-MS.

关 键 词：Hantzsch反应 氢化喹啉羧酸酯 合成 

分 类 号：O626.2[理学—有机化学]